Entity Details

Primary name FA8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00451
EntryNameFA8_HUMAN
FullNameCoagulation factor VIII
TaxID9606
Evidenceevidence at protein level
Length2351
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesF8

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0005507 copper ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006953 acute-phase response
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0016491 oxidoreductase activity
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0031093 platelet alpha granule lumen
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0048208 COPII vesicle coating
GO:2000267 negative regulation of blood coagulation, intrinsic pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000421 Coagulation factor 5/8 C-terminal domainDomainDomain
IPR001117 Multicopper oxidase, type 1DomainDomain
IPR008972 CupredoxinFamilyHomologous superfamily
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR011706 Multicopper oxidase, C-terminalDomainDomain
IPR011707 Multicopper oxidase, N-termianlDomainDomain
IPR024715 Coagulation factor 5/8-likeFamilyFamily
IPR033138 Multicopper oxidases, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00055 Drotrecogin alfaDrugbankbiotech
DB00100 Coagulation Factor IX (Recombinant)Drugbankbiotech
DB06050 TB-402Drugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB11300 ThrombinDrugbankbiotech
DB11312 Protein CDrugbankbiotech
DB11571 Human thrombinDrugbankbiotech
DB11572 Thrombin alfaDrugbankbiotech
DB12872 Vonicog AlfaDrugbankbiotech
DB13133 Von Willebrand Factor HumanDrugbankbiotech
DB13151 Anti-inhibitor coagulant complexDrugbankbiotech
DB13152 Coagulation Factor IX HumanDrugbankbiotech
DB13884 Albutrepenonacog alfaDrugbankbiotech
DB13933 Nonacog beta pegolDrugbankbiotech
DB14700 Damoctocog alfa pegolDrugbankbiotech