Entity Details

Primary name ARGI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05089
EntryNameARGI1_HUMAN
FullNameArginase-1
TaxID9606
Evidenceevidence at protein level
Length322
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesARG1

GO terms

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GOName
GO:0000050 urea cycle
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002250 adaptive immune response
GO:0004053 arginase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006527 arginine catabolic process
GO:0007568 aging
GO:0009635 response to herbicide
GO:0010042 response to manganese ion
GO:0010043 response to zinc ion
GO:0010269 response to selenium ion
GO:0010963 regulation of L-arginine import
GO:0014075 response to amine
GO:0019547 arginine catabolic process to ornithine
GO:0030145 manganese ion binding
GO:0030324 lung development
GO:0032964 collagen biosynthetic process
GO:0033189 response to vitamin A
GO:0033197 response to vitamin E
GO:0035578 azurophil granule lumen
GO:0035580 specific granule lumen
GO:0042130 negative regulation of T cell proliferation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043200 response to amino acid
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0046007 negative regulation of activated T cell proliferation
GO:0046686 response to cadmium ion
GO:0048678 response to axon injury
GO:0051597 response to methylmercury
GO:0060056 mammary gland involution
GO:0060135 maternal process involved in female pregnancy
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070965 positive regulation of neutrophil mediated killing of fungus
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0071377 cellular response to glucagon stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000552 negative regulation of T-helper 2 cell cytokine production

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic granule

Domains

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DomainNameCategoryType
IPR006035 UreohydrolaseFamilyFamily
IPR014033 ArginaseFamilyFamily
IPR020855 Ureohydrolase, manganese-binding siteSiteBinding site
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
207800 OMIMArgininemia (ARGIN)A rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00129 OrnithineDrugbanksmall molecule
DB01983 2(S)-Amino-6-Boronohexanoic AcidDrugbanksmall molecule
DB02381 nor-NOHADrugbanksmall molecule
DB02499 Dinor-N(Omega)-Hydroxy-L-ArginineDrugbanksmall molecule
DB02689 S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-CysteineDrugbanksmall molecule
DB03144 N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineDrugbanksmall molecule
DB03731 S-2-(Boronoethyl)-L-CysteineDrugbanksmall molecule
DB03904 UreaDrugbanksmall molecule
DB04197 Descarboxy-nor-N(Omega)-Hydroxy-L-ArginineDrugbanksmall molecule
DB04530 S,S-(2-Hydroxyethyl)ThiocysteineDrugbanksmall molecule
DB04585 DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACIDDrugbanksmall molecule
DB04648 S-propylamine-L-cysteineDrugbanksmall molecule
DB06757 ManganeseDrugbanksmall molecule