Entity Details

Primary name TF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13726
EntryNameTF_HUMAN
FullNameTissue factor
TaxID9606
Evidenceevidence at protein level
Length295
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesF3

GO terms

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GOName
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002020 protease binding
GO:0002541 activation of plasma proteins involved in acute inflammatory response
GO:0002543 activation of blood coagulation via clotting cascade
GO:0004896 cytokine receptor activity
GO:0005543 phospholipid binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007596 blood coagulation
GO:0007598 blood coagulation, extrinsic pathway
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0019221 cytokine-mediated signaling pathway
GO:0030335 positive regulation of cell migration
GO:0031233 intrinsic component of external side of plasma membrane
GO:0032757 positive regulation of interleukin-8 production
GO:0045766 positive regulation of angiogenesis
GO:0050927 positive regulation of positive chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0062023 collagen-containing extracellular matrix
GO:1905286 serine-type peptidase complex
GO:2000264 negative regulation of blood coagulation, extrinsic pathway

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR001187 Tissue factorFamilyFamily
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015373 Interferon/interleukin receptor domainDomainDomain
IPR030472 Tissue factor, conserved siteSiteConserved site
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00036 Coagulation factor VIIa Recombinant HumanDrugbankbiotech
DB06552 rNAPc2Drugbankbiotech
DB07207 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINEDrugbanksmall molecule
DB07247 [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREADrugbanksmall molecule
DB08232 [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acidDrugbanksmall molecule
DB13150 Coagulation factor VII humanDrugbankbiotech