Entity Details

Primary name GNAT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19087
EntryNameGNAT2_HUMAN
FullNameGuanine nucleotide-binding protein G(t) subunit alpha-2
TaxID9606
Evidenceevidence at protein level
Length354
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesGNAT2

GO terms

Show/Hide Table
GOName
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0001664 G protein-coupled receptor binding
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0006457 protein folding
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0008020 G protein-coupled photoreceptor activity
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0042622 photoreceptor outer segment membrane
GO:0046872 metal ion binding
GO:0050908 detection of light stimulus involved in visual perception

Subcellular Location

Show/Hide Table
Subcellular Location
Cell projection
Photoreceptor inner segment

Domains

Show/Hide Table
DomainNameCategoryType
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunitFamilyFamily
IPR001408 G-protein alpha subunit, group IFamilyFamily
IPR011025 G protein alpha subunit, helical insertionFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
613856 OMIMAchromatopsia 4 (ACHM4)An ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
GNAT2_HUMANA4_HUMANBioGRID21832049 details
GNAT2_HUMANADRB2_HUMANBioGRID24561123 details