Entity Details

Primary name CP3A7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24462
EntryNameCP3A7_HUMAN
FullNameCytochrome P450 3A7
TaxID9606
Evidenceevidence at protein level
Length503
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0002933 lipid hydroxylation
GO:0005506 iron ion binding
GO:0008210 estrogen metabolic process
GO:0008395 steroid hydroxylase activity
GO:0020037 heme binding
GO:0042573 retinoic acid metabolic process
GO:0004497 monooxygenase activity
GO:0005789 endoplasmic reticulum membrane
GO:0008401 retinoic acid 4-hydroxylase activity
GO:0050649 testosterone 6-beta-hydroxylase activity
GO:0006694 steroid biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0019825 oxygen binding
GO:0042572 retinol metabolic process
GO:0070989 oxidative demethylation
GO:0101021 estrogen 2-hydroxylase activity
GO:0062183 all-trans retinoic acid 18-hydroxylase activity
GO:0070330 aromatase activity
GO:0101020 estrogen 16-alpha-hydroxylase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002402 Cytochrome P450, E-class, group IIFamilyFamily
IPR008072 Cytochrome P450, E-class, CYP3AFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00176 FluvoxamineDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00199 ErythromycinDrugbanksmall molecule
DB00203 SildenafilDrugbanksmall molecule
DB00220 NelfinavirDrugbanksmall molecule
DB00224 IndinavirDrugbanksmall molecule
DB00238 NevirapineDrugbanksmall molecule
DB00250 DapsoneDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00257 ClotrimazoleDrugbanksmall molecule
DB00281 LidocaineDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00342 TerfenadineDrugbanksmall molecule
DB00343 DiltiazemDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00398 SorafenibDrugbanksmall molecule
DB00401 NisoldipineDrugbanksmall molecule
DB00404 AlprazolamDrugbanksmall molecule
DB00409 RemoxiprideDrugbanksmall molecule
DB00439 CerivastatinDrugbanksmall molecule
DB00443 BetamethasoneDrugbanksmall molecule
DB00446 ChloramphenicolDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00490 BuspironeDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00528 LercanidipineDrugbanksmall molecule
DB00537 CiprofloxacinDrugbanksmall molecule
DB00541 VincristineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00582 VoriconazoleDrugbanksmall molecule
DB00588 Fluticasone propionateDrugbanksmall molecule
DB00593 EthosuximideDrugbanksmall molecule
DB00599 ThiopentalDrugbanksmall molecule
DB00604 CisaprideDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00620 TriamcinoloneDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00625 EfavirenzDrugbanksmall molecule
DB00635 PrednisoneDrugbanksmall molecule
DB00637 AstemizoleDrugbanksmall molecule
DB00643 MebendazoleDrugbanksmall molecule
DB00656 TrazodoneDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00683 MidazolamDrugbanksmall molecule
DB00705 DelavirdineDrugbanksmall molecule
DB00731 NateglinideDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00762 IrinotecanDrugbanksmall molecule
DB00780 PhenelzineDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00802 AlfentanilDrugbanksmall molecule
DB00813 FentanylDrugbanksmall molecule
DB00829 DiazepamDrugbanksmall molecule
DB00877 SirolimusDrugbanksmall molecule
DB00897 TriazolamDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00916 MetronidazoleDrugbanksmall molecule
DB00921 BuprenorphineDrugbanksmall molecule
DB00938 SalmeterolDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB00962 ZaleplonDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01054 NitrendipineDrugbanksmall molecule
DB01058 PraziquantelSwissprotsmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01100 PimozideDrugbanksmall molecule
DB01114 ChlorpheniramineDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01166 CilostazolDrugbanksmall molecule
DB01167 ItraconazoleDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01184 DomperidoneDrugbanksmall molecule
DB01201 RifapentineDrugbanksmall molecule
DB01216 FinasterideDrugbanksmall molecule
DB01222 BudesonideDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01227 LevacetylmethadolDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01232 SaquinavirDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01248 DocetaxelDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB01601 LopinavirDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB05804 Prasterone sulfateSwissprotsmall molecule
DB06287 TemsirolimusDrugbanksmall molecule
DB06412 OxymetholoneDrugbanksmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB06730 GestodeneDrugbanksmall molecule
DB06731 SeproxetineSwissprotsmall molecule
DB08865 CrizotinibDrugbanksmall molecule
DB08906 Fluticasone furoateDrugbanksmall molecule
DB08930 DolutegravirDrugbanksmall molecule
DB09054 IdelalisibDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09065 CobicistatSwissprotsmall molecule
DB09102 DaclatasvirDrugbanksmall molecule
DB09205 MoxisylyteDrugbanksmall molecule
DB09212 LoxoprofenDrugbanksmall molecule
DB09568 Omega-3-carboxylic acidsDrugbanksmall molecule
DB11574 ElbasvirDrugbanksmall molecule
DB11605 MyrrhDrugbanksmall molecule
DB11652 TucatinibDrugbanksmall molecule
DB11691 NaldemedineDrugbanksmall molecule
DB11703 AcalabrutinibDrugbanksmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB11792 MirodenafilSwissprotsmall molecule
DB11853 RelugolixDrugbanksmall molecule
DB11951 LemborexantDrugbanksmall molecule
DB11979 ElagolixDrugbanksmall molecule
DB11994 DiacereinDrugbanksmall molecule
DB12070 LetermovirDrugbanksmall molecule
DB12130 LorlatinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB12307 ForetinibDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB12483 CopanlisibDrugbanksmall molecule
DB12887 TazemetostatDrugbanksmall molecule
DB13141 Ambroxol acefyllinateSwissprotsmall molecule
DB13174 RheinDrugbanksmall molecule
DB13179 TroleandomycinDrugbanksmall molecule
DB13867 FluticasoneDrugbanksmall molecule
DB13878 PibrentasvirDrugbanksmall molecule
DB13879 GlecaprevirDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule
DB14538 Hydrocortisone aceponateDrugbanksmall molecule
DB14539 Hydrocortisone acetateDrugbanksmall molecule
DB14540 Hydrocortisone butyrateDrugbanksmall molecule
DB14541 Hydrocortisone cypionateDrugbanksmall molecule
DB14542 Hydrocortisone phosphateDrugbanksmall molecule
DB14543 Hydrocortisone probutateDrugbanksmall molecule
DB14544 Hydrocortisone valerateDrugbanksmall molecule
DB14631 Prednisolone phosphateDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule
DB15305 RisdiplamSwissprotsmall molecule
DB15685 SelpercatinibDrugbanksmall molecule

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