Entity Details

Primary name CGL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32929
EntryNameCGL_HUMAN
FullNameCystathionine gamma-lyase
TaxID9606
Evidenceevidence at protein level
Length405
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesCTH

GO terms

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GOName
GO:0000098 sulfur amino acid catabolic process
GO:0004123 cystathionine gamma-lyase activity
GO:0005516 calmodulin binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006534 cysteine metabolic process
GO:0016846 carbon-sulfur lyase activity
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019343 cysteine biosynthetic process via cystathionine
GO:0019344 cysteine biosynthetic process
GO:0019346 transsulfuration
GO:0030170 pyridoxal phosphate binding
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044524 protein sulfhydration
GO:0044540 L-cystine L-cysteine-lyase (deaminating)
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051289 protein homotetramerization
GO:0070062 extracellular exosome
GO:0070814 hydrogen sulfide biosynthetic process
GO:0080146 L-cysteine desulfhydrase activity
GO:1904831 positive regulation of aortic smooth muscle cell differentiation
GO:1990830 cellular response to leukemia inhibitory factor
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzymeFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
219500 OMIMCystathioninuria (CSTNU)Autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00151 CysteineDrugbanksmall molecule
DB02328 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic AcidDrugbanksmall molecule
DB03928 Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-OxadiazolDrugbanksmall molecule
DB04217 L-2-amino-3-butynoic acidDrugbanksmall molecule

Interactions

6 interactions