Entity Details

Primary name ATP7B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35670
EntryNameATP7B_HUMAN
FullNameCopper-transporting ATPase 2
TaxID9606
Evidenceevidence at protein level
Length1465
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesATP7B

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005375 copper ion transmembrane transporter activity
GO:0005507 copper ion binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005887 integral component of plasma membrane
GO:0006825 copper ion transport
GO:0006878 cellular copper ion homeostasis
GO:0015677 copper ion import
GO:0016020 membrane
GO:0032588 trans-Golgi network membrane
GO:0034220 ion transmembrane transport
GO:0043682 P-type divalent copper transporter activity
GO:0046688 response to copper ion
GO:0051208 sequestering of calcium ion
GO:0060003 copper ion export
GO:0140581 P-type monovalent copper transporter activity
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus
Golgi apparatus membrane
Late endosome
Mitochondrion

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR006121 Heavy metal-associated domain, HMADomainDomain
IPR006122 Heavy metal-associated domain, copper ion-bindingDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR017969 Heavy-metal-associated, conserved siteSiteConserved site
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR027256 P-type ATPase, subfamily IBFamilyFamily
IPR036163 Heavy metal-associated domain superfamilyFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB09130 CopperDrugbanksmall molecule