Entity Details

Primary name HNMT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50135
EntryNameHNMT_HUMAN
FullNameHistamine N-methyltransferase
TaxID9606
Evidenceevidence at protein level
Length292
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesHNMT

GO terms

Show/Hide Table
GOName
GO:0001692 histamine metabolic process
GO:0001695 histamine catabolic process
GO:0002347 response to tumor cell
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006548 histidine catabolic process
GO:0006972 hyperosmotic response
GO:0007420 brain development
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0014075 response to amine
GO:0032259 methylation
GO:0035902 response to immobilization stress
GO:0042220 response to cocaine
GO:0043005 neuron projection
GO:0046539 histamine N-methyltransferase activity
GO:0051384 response to glucocorticoid
GO:0070062 extracellular exosome
GO:0070555 response to interleukin-1

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR016673 Histamine N-methyltransferase-likeFamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00613 AmodiaquineDrugbanksmall molecule
DB01103 QuinacrineDrugbanksmall molecule
DB01752 S-adenosyl-L-homocysteineDrugbanksmall molecule
DB04655 MetoprineDrugbanksmall molecule
DB05381 HistamineDrugbanksmall molecule
DB07106 SKF-91488Drugbanksmall molecule
DB13875 HarmalineDrugbanksmall molecule

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
HNMT_HUMANKCC2D_HUMANBioGRID, IntAct21988832 details
HNMT_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
HNMT_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
HNMT_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
HNMT_HUMANCLK1_HUMANBioGRID26167880 details