Entity Details

Primary name SSDH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51649
EntryNameSSDH_HUMAN
FullNameSuccinate-semialdehyde dehydrogenase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length535
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesALDH5A1

GO terms

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GOName
GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006105 succinate metabolic process
GO:0006536 glutamate metabolic process
GO:0007417 central nervous system development
GO:0009450 gamma-aminobutyric acid catabolic process
GO:0009791 post-embryonic development
GO:0042135 neurotransmitter catabolic process
GO:0042802 identical protein binding

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR010102 Succinate semialdehyde dehydrogenaseFamilyFamily
IPR015590 Aldehyde dehydrogenase domainDomainDomain
IPR016160 Aldehyde dehydrogenase, cysteine active siteSiteConserved site
IPR016161 Aldehyde/histidinol dehydrogenaseFamilyHomologous superfamily
IPR016162 Aldehyde dehydrogenase, N-terminalFamilyHomologous superfamily
IPR016163 Aldehyde dehydrogenase, C-terminalFamilyHomologous superfamily
IPR029510 Aldehyde dehydrogenase, glutamic acid active siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00139 Succinic acidDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00534 ChlormerodrinDrugbanksmall molecule
DB09072 Sodium oxybateSwissprotsmall molecule