Entity Details

Primary name STA5B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51692
EntryNameSTA5B_HUMAN
FullNameSignal transducer and activator of transcription 5B
TaxID9606
Evidenceevidence at protein level
Length787
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesSTAT5B

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001553 luteinization
GO:0001779 natural killer cell differentiation
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006952 defense response
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0019218 regulation of steroid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0019915 lipid storage
GO:0030856 regulation of epithelial cell differentiation
GO:0032355 response to estradiol
GO:0032743 positive regulation of interleukin-2 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0032870 cellular response to hormone stimulus
GO:0033077 T cell differentiation in thymus
GO:0035259 glucocorticoid receptor binding
GO:0035723 interleukin-15-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038111 interleukin-7-mediated signaling pathway
GO:0038113 interleukin-9-mediated signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0042127 regulation of cell population proliferation
GO:0042448 progesterone metabolic process
GO:0042802 identical protein binding
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046543 development of secondary female sexual characteristics
GO:0046544 development of secondary male sexual characteristics
GO:0046983 protein dimerization activity
GO:0048541 Peyer's patch development
GO:0050729 positive regulation of inflammatory response
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070670 response to interleukin-4
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0097531 mast cell migration

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001217 Transcription factor STATFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012345 STAT transcription factor, DNA-binding, N-terminalFamilyHomologous superfamily
IPR013799 STAT transcription factor, protein interactionDomainDomain
IPR013800 STAT transcription factor, all-alpha domainDomainDomain
IPR013801 STAT transcription factor, DNA-bindingDomainDomain
IPR015988 STAT transcription factor, coiled coilFamilyHomologous superfamily
IPR035858 STAT5a/5bFamilyFamily
IPR035886 STAT5b, SH2 domainDomainDomain
IPR036535 STAT transcription factor, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
245590 OMIMGrowth hormone insensitivity with immunodeficiency (GHII)A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to exogeneous growth hormone therapy, and recurrent infections. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule

Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
STA5B_HUMANNMI_HUMANBioGRID, HPRD, IntAct9989503 details
STA5B_HUMANPTN1_HUMANBioGRID, HPRD, MINT12237455 details
STA5B_HUMANIL2RB_HUMANBioGRID, HPRD, MINT10602027 details
STA5B_HUMANINSR_HUMANBioGRID, HPRD, MINT10830280 12456798 9122188 9428692 details
STA5B_HUMANIL15_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANTFG_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANHAX1_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANSRTD1_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANAFTIN_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANDMRTA_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANGHR_HUMANBioGRID, HPRD, IntAct25241761 8923468 details
STA5B_HUMANCTLA4_HUMANBioGRID, HPRD, IntAct16476059 25241761 details
STA5B_HUMANZN410_HUMANIntAct32296183 details
STA5B_HUMANPPL13_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANCAF1A_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANMED25_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANSTAC_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANP55G_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANTSSK3_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANCDN1A_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANRT06_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANLMO4_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANRBBP4_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANSUOX_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANSTA5B_HUMANBioGRID, HPRD, IntAct12089361 14704793 20962278 22729867 31175292 details
STA5B_HUMANABL1_HUMANIntAct31175292 details
STA5B_HUMANJAK2_HUMANBioGRID, HPRD12538627 24354892 9047382 9575217 details
STA5B_HUMANPTN11_HUMANBioGRID, HPRD10617656 details
STA5B_HUMANJAK1_HUMANBioGRID9047382 details
STA5B_HUMANJAK3_HUMANBioGRID9047382 details
STA5B_HUMANELP2_HUMANBioGRID, HPRD10954736 details
STA5B_HUMANA4_HUMANBioGRID21832049 details
STA5B_HUMANKIT_HUMANBioGRID, HPRD10358045 17554063 details
STA5B_HUMANROA2_HUMANBioGRID32296183 details
STA5B_HUMANNCOR2_HUMANHPRD11726519 details
STA5B_HUMANCENPJ_HUMANHPRD12198240 details
STA5B_HUMANEPOR_HUMANHPRD15644415 8977232 details
STA5B_HUMANSTAP2_HUMANHPRD, MINT15611091 details
STA5B_HUMANEGFR_HUMANBioGRID, HPRD, MINT10558875 11751923 16729043 22729867 details
STA5B_HUMANERBB4_HUMANHPRD, MINT16729043 details
STA5B_HUMANDNJA3_HUMANIntAct21106534 details
STA5B_HUMANSTAT3_HUMANBioGRID, HPRD, IntAct25241761 9398404 details
STA5B_HUMANIL2RA_HUMANHPRD, IntAct10602027 11485747 details
STA5B_HUMANSTA5A_HUMANBioGRID, HPRD, IntAct28514442 9528750 details
STA5B_HUMANEPHA4_HUMANIntAct31413325 details
STA5B_HUMANGCR_HUMANBioGRID, HPRD11158330 8878484 9528750 details
STA5B_HUMANSHC1_HUMANBioGRID, HPRD10996427 details
STA5B_HUMANCD3Z_HUMANBioGRID, HPRD9880255 details
STA5B_HUMANCCR5_HUMANBioGRID11350939 details
STA5B_HUMANPTN6_HUMANBioGRID, HPRD9211920 details
STA5B_HUMANPO2F1_HUMANBioGRID, HPRD14645506 16025120 details
STA5B_HUMANFGFR2_HUMANBioGRID21464042 details
STA5B_HUMANPRGR_HUMANBioGRID21464042 details
STA5B_HUMANPRLR_HUMANBioGRID20962278 details
STA5B_HUMANMK01_HUMANHPRD10996427 details
STA5B_HUMANSRC_HUMANHPRD12621061 details
STA5B_HUMANPTN2_HUMANHPRD11773439 15588985 details
STA5B_HUMANRARA_HUMANHPRD11929748 details
STA5B_HUMANEP300_HUMANHPRD14726487 9989503 details
STA5B_HUMANTIE2_HUMANHPRD14726409 details
STA5B_HUMANCXCR4_HUMANHPRD10506573 details
STA5B_HUMANIL7RA_HUMANHPRD7719938 details
STA5B_HUMANCRK_HUMANHPRD10720694 11097834 9845531 details
STA5B_HUMANCBL_HUMANHPRD12193575 details
STA5B_HUMANPGFRB_HUMANHPRD9484840 details
STA5B_HUMANPGFRA_HUMANHPRD9484840 details
STA5B_HUMANSTAT1_HUMANHPRD10358045 details
STA5B_HUMANCRKL_HUMANHPRD10720694 11097834 9845531 details
STA5B_HUMANPP2AA_HUMANHPRD11440634 details
STA5B_HUMANETS1_HUMANHPRD10815800 details
STA5B_HUMANETS2_HUMANHPRD10815800 details