Entity Details

Primary name IOD3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55073
EntryNameIOD3_HUMAN
FullNameThyroxine 5-deiodinase
TaxID9606
Evidenceevidence at protein level
Length304
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesDIO3

GO terms

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GOName
GO:0004800 thyroxine 5'-deiodinase activity
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0033798 thyroxine 5-deiodinase activity
GO:0040018 positive regulation of multicellular organism growth
GO:0042403 thyroid hormone metabolic process
GO:0042404 thyroid hormone catabolic process
GO:0042446 hormone biosynthetic process
GO:0043231 intracellular membrane-bounded organelle
GO:0046549 retinal cone cell development
GO:0097474 retinal cone cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Endosome membrane

Domains

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DomainNameCategoryType
IPR000643 Iodothyronine deiodinaseFamilyFamily
IPR008261 Iodothyronine deiodinase, active siteSiteActive site
IPR027252 Iodothyronine deiodinase I/IIIFamilyFamily
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09100 Thyroid, porcineDrugbankbiotech
DB09333 Iopodic acidDrugbanksmall molecule

Interactions

4 interactions