Entity Details

Primary name S10AC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP80511
EntryNameS10AC_HUMAN
FullNameProtein S100-A12
TaxID9606
Evidenceevidence at protein level
Length92
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesS100A12

GO terms

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GOName
GO:0002548 monocyte chemotaxis
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006805 xenobiotic metabolic process
GO:0006954 inflammatory response
GO:0008270 zinc ion binding
GO:0030593 neutrophil chemotaxis
GO:0031640 killing of cells of other organism
GO:0034774 secretory granule lumen
GO:0042742 defense response to bacterium
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043312 neutrophil degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0045576 mast cell activation
GO:0048306 calcium-dependent protein binding
GO:0050729 positive regulation of inflammatory response
GO:0050786 RAGE receptor binding
GO:0050832 defense response to fungus
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR001751 S100/Calbindin-D9k, conserved siteSiteConserved site
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013787 S100/CaBP-9k-type, calcium binding, subdomainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00768 OlopatadineDrugbanksmall molecule
DB01025 AmlexanoxDrugbanksmall molecule