Entity Details

Primary name FOLH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04609
EntryNameFOLH1_HUMAN
FullNameGlutamate carboxypeptidase 2
TaxID9606
Evidenceevidence at protein level
Length750
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesFOLH1

GO terms

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GOName
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0009066 aspartate family amino acid metabolic process
GO:0009986 cell surface
GO:0016020 membrane
GO:0016805 dipeptidase activity
GO:0035609 C-terminal protein deglutamylation
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:1904492 Ac-Asp-Glu binding
GO:1904493 tetrahydrofolyl-poly(glutamate) polymer binding

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR003137 PA domainDomainDomain
IPR007365 Transferrin receptor-like, dimerisation domainDomainDomain
IPR007484 Peptidase M28DomainDomain
IPR036757 Transferrin receptor-like, dimerisation domain superfamilyFamilyHomologous superfamily
IPR039373 Glutamate carboxypeptidase 2-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00089 Capromab pendetideDrugbankbiotech
DB00142 Glutamic acidDrugbanksmall molecule
DB06928 (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACIDDrugbanksmall molecule
DB07754 DCFBCDrugbanksmall molecule
DB08835 Spaglumic AcidDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
FOLH1_HUMANMTAP_HUMANBioGRID, IntAct21988832 details
FOLH1_HUMANRS3_HUMANBioGRID, IntAct21988832 details
FOLH1_HUMANTTMP_HUMANBioGRID, IntAct32296183 details
FOLH1_HUMANHDAC1_HUMANBioGRID29448109 details