Entity Details

Primary name ERBB4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15303
EntryNameERBB4_HUMAN
FullNameReceptor tyrosine-protein kinase erbB-4
TaxID9606
Evidenceevidence at protein level
Length1308
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesERBB4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000976 transcription cis-regulatory region binding
GO:0001755 neural crest cell migration
GO:0001934 positive regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0007507 heart development
GO:0007595 lactation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009880 embryonic pattern specification
GO:0009925 basal plasma membrane
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016323 basolateral plasma membrane
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021551 central nervous system morphogenesis
GO:0021889 olfactory bulb interneuron differentiation
GO:0030334 regulation of cell migration
GO:0033674 positive regulation of kinase activity
GO:0038128 ERBB2 signaling pathway
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045165 cell fate commitment
GO:0045211 postsynaptic membrane
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046777 protein autophosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060644 mammary gland epithelial cell differentiation
GO:0060749 mammary gland alveolus development
GO:0061026 cardiac muscle tissue regeneration
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099061 integral component of postsynaptic density membrane
GO:2000010 positive regulation of protein localization to cell surface
GO:2000145 regulation of cell motility
GO:2001223 negative regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615515 OMIMAmyotrophic lateral sclerosis 19 (ALS19)A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB08916 AfatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

177 interactions

InteractorPartnerSourcesPublicationsLink
ERBB4_HUMANDLG4_HUMANBioGRID, HPRD, IntAct, MINT10725395 10839362 12716924 16767099 17018285 details
ERBB4_HUMANSNTB2_HUMANBioGRID, HPRD, MINT10725395 details
ERBB4_HUMANDLG2_HUMANBioGRID, HPRD, MINT10725395 details
ERBB4_HUMANDLG3_HUMANBioGRID, HPRD, MINT10725395 12175853 details
ERBB4_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT16729043 22973453 24658140 25140053 details
ERBB4_HUMANSHC1_HUMANBioGRID, HPRD, IntAct, MINT16273093 16729043 22973453 24658140 9019162 details
ERBB4_HUMANNCK2_HUMANBioGRID, MINT16729043 22973453 details
ERBB4_HUMANPTN11_HUMANBioGRID, MINT16729043 22973453 28065597 details
ERBB4_HUMANP85B_HUMANBioGRID, HPRD, MINT16729043 22973453 details
ERBB4_HUMANABL2_HUMANBioGRID, MINT16273093 22973453 details
ERBB4_HUMANABL1_HUMANBioGRID, MINT16273093 22973453 details
ERBB4_HUMANKSYK_HUMANBioGRID, MINT16273093 22973453 details
ERBB4_HUMANRASA1_HUMANBioGRID, MINT16273093 22973453 details
ERBB4_HUMANANS1B_HUMANBioGRID, MINT16273093 details
ERBB4_HUMANANS1A_HUMANBioGRID, MINT16273093 details
ERBB4_HUMANEGFR_HUMANBioGRID, HPRD, IntAct10572067 16061658 23153581 25140053 25315821 details
ERBB4_HUMANERBB3_HUMANBioGRID, HPRD, IntAct10572067 20227043 25315821 7689552 details
ERBB4_HUMANERBB2_HUMANBioGRID, DIP, HPRD, IntAct10572067 10839362 16767099 21203579 24557338 25315821 30898150 8816440 details
ERBB4_HUMANWWOX_HUMANBioGRID, IntAct16061658 19047365 20943952 22584572 24550385 details
ERBB4_HUMANHDAC6_HUMANBioGRID, IntAct20029029 31980649 details
ERBB4_HUMANTROP_HUMANBioGRID, UniProt17360433 21191175 details
ERBB4_HUMANHS90A_HUMANBioGRID, IntAct22939624 24658140 details
ERBB4_HUMANG3P_HUMANIntAct24658140 details
ERBB4_HUMANCOF1_HUMANBioGRID, IntAct24658140 31980649 details
ERBB4_HUMANYAP1_HUMANBioGRID, HPRD, MINT12807903 15023535 16061658 19047365 25283809 details
ERBB4_HUMANDLG1_HUMANBioGRID, HPRD, MINT12175853 24550280 details
ERBB4_HUMANBYST_HUMANBioGRID, DIP17360433 details
ERBB4_HUMANERBB4_HUMANBioGRID, DIP, HPRD10572067 16170367 18334220 20943952 25315821 8816440 details
ERBB4_HUMANITCH_HUMANBioGRID, DIP17463226 18334649 details
ERBB4_HUMANPTPRH_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTPRT_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS14_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS10_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANMPIP3_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS18_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS16_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTN12_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS21_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS6_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANILKAP_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANMTMR2_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANMTMR6_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANMTMR9_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPPM1A_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPPM1B_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPPM1F_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTPC1_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS19_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANSTYX_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANTAB1_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTN6_HUMANBioGRID, MINT22973453 28065597 details
ERBB4_HUMANPTN7_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANS10A4_HUMANUniProt30083275 details
ERBB4_HUMANZN532_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTHIO_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTM14A_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTM134_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANSYNEM_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANAP180_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANSELK_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANS10AA_HUMANIntAct31980649 details
ERBB4_HUMANRTN4_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTMG4_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANPRDX5_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANPIN4_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANLRRC7_HUMANIntAct31980649 details
ERBB4_HUMANI2BP2_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANGBRL2_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANFKB1A_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTV23B_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTMA7_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANSIM20_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTM230_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANERG28_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANF241B_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANALDOA_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANLRIG1_HUMANBioGRID, IntAct15282549 15345710 20126551 details
ERBB4_HUMANNRG1_HUMANBioGRID, HPRD, IntAct10537356 28988771 7721889 8062828 9168115 9565587 details
ERBB4_HUMANGRB7_HUMANBioGRID, IntAct22973453 29290818 details
ERBB4_HUMANCRK_HUMANBioGRID, HPRD16729043 22973453 details
ERBB4_HUMANNCK1_HUMANBioGRID16729043 22973453 details
ERBB4_HUMANRNF41_HUMANBioGRID, HPRD11867753 27648936 details
ERBB4_HUMANNRG2_HUMANBioGRID, HPRD15358134 9168114 9168115 details
ERBB4_HUMANWWP1_HUMANBioGRID19047365 19561640 details
ERBB4_HUMANNEDD4_HUMANBioGRID19193720 details
ERBB4_HUMANTAB2_HUMANBioGRID17018285 details
ERBB4_HUMANAP2C_HUMANBioGRID20943952 details
ERBB4_HUMANPTN20_HUMANBioGRID28065597 details
ERBB4_HUMANPTN21_HUMANBioGRID25681686 details
ERBB4_HUMANFYN_HUMANBioGRID17460065 details
ERBB4_HUMANNTRK2_HUMANBioGRID25052836 details
ERBB4_HUMANMUC4_HUMANBioGRID25315821 details
ERBB4_HUMANLRIG3_HUMANBioGRID20126551 details
ERBB4_HUMANS10AB_HUMANBioGRID31980649 details
ERBB4_HUMANBCAR3_HUMANBioGRID22973453 details
ERBB4_HUMANBLK_HUMANBioGRID22973453 details
ERBB4_HUMANFES_HUMANBioGRID22973453 details
ERBB4_HUMANFGR_HUMANBioGRID22973453 details
ERBB4_HUMANGRAP2_HUMANBioGRID22973453 details
ERBB4_HUMANGRB10_HUMANBioGRID22973453 details
ERBB4_HUMANHCK_HUMANBioGRID22973453 details
ERBB4_HUMANHSH2D_HUMANBioGRID22973453 details
ERBB4_HUMANSHIP2_HUMANBioGRID22973453 details
ERBB4_HUMANITK_HUMANBioGRID22973453 details
ERBB4_HUMANLCK_HUMANBioGRID22973453 details
ERBB4_HUMANLCP2_HUMANBioGRID22973453 details
ERBB4_HUMANLYN_HUMANBioGRID22973453 details
ERBB4_HUMANMATK_HUMANBioGRID22973453 details
ERBB4_HUMANP85A_HUMANBioGRID22973453 details
ERBB4_HUMANP55G_HUMANBioGRID22973453 details
ERBB4_HUMANPLCG1_HUMANBioGRID22973453 details
ERBB4_HUMANPLCG2_HUMANBioGRID22973453 details
ERBB4_HUMANPTK6_HUMANBioGRID22973453 details
ERBB4_HUMANSH2B1_HUMANBioGRID22973453 details
ERBB4_HUMANSH2B2_HUMANBioGRID22973453 details
ERBB4_HUMANSH2B3_HUMANBioGRID22973453 details
ERBB4_HUMANSH21A_HUMANBioGRID22973453 details
ERBB4_HUMANSH21B_HUMANBioGRID22973453 details
ERBB4_HUMANSH22A_HUMANBioGRID22973453 details
ERBB4_HUMANSH2D3_HUMANBioGRID22973453 details
ERBB4_HUMAN3BP2_HUMANBioGRID22973453 details
ERBB4_HUMANSHB_HUMANBioGRID22973453 details
ERBB4_HUMANSHC2_HUMANBioGRID22973453 details
ERBB4_HUMANSHC3_HUMANBioGRID22973453 details
ERBB4_HUMANSHC4_HUMANBioGRID22973453 details
ERBB4_HUMANSHD_HUMANBioGRID22973453 details
ERBB4_HUMANSLAP1_HUMANBioGRID22973453 details
ERBB4_HUMANSLAP2_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS1_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS2_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS3_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS5_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS6_HUMANBioGRID22973453 details
ERBB4_HUMANSRC_HUMANBioGRID22973453 details
ERBB4_HUMANSTAP1_HUMANBioGRID22973453 details
ERBB4_HUMANTEC_HUMANBioGRID22973453 details
ERBB4_HUMANTNS2_HUMANBioGRID22973453 details
ERBB4_HUMANTENS1_HUMANBioGRID22973453 details
ERBB4_HUMANTENS3_HUMANBioGRID22973453 details
ERBB4_HUMANTENS4_HUMANBioGRID22973453 details
ERBB4_HUMANTXK_HUMANBioGRID22973453 details
ERBB4_HUMANVAV_HUMANBioGRID22973453 details
ERBB4_HUMANVAV2_HUMANBioGRID22973453 details
ERBB4_HUMANVAV3_HUMANBioGRID22973453 details
ERBB4_HUMANYES_HUMANBioGRID22973453 details
ERBB4_HUMANZAP70_HUMANBioGRID22973453 details
ERBB4_HUMANCRKL_HUMANMINT16729043 details
ERBB4_HUMANSTA5B_HUMANHPRD, MINT16729043 details
ERBB4_HUMANNMDZ1_HUMANIntAct16767099 details
ERBB4_HUMANHS90B_HUMANIntAct22939624 details
ERBB4_HUMANTROAP_HUMANDIP17360433 details
ERBB4_HUMANHBEGF_HUMANHPRD, UniProt9135143 details
ERBB4_HUMANSTA5A_HUMANBioGRID, HPRD15534001 16729043 22584572 details
ERBB4_HUMANCD44_HUMANBioGRID, HPRD11825873 details
ERBB4_HUMANMUC1_HUMANBioGRID, HPRD11278868 12939402 details
ERBB4_HUMANEREG_HUMANBioGRID, HPRD9419975 details
ERBB4_HUMANNCOR1_HUMANBioGRID17018285 details
ERBB4_HUMANPIAS3_HUMANBioGRID22584572 details
ERBB4_HUMANPIAS4_HUMANBioGRID22584572 details
ERBB4_HUMANTIF1B_HUMANBioGRID20858735 details
ERBB4_HUMANMDM2_HUMANBioGRID20858735 details
ERBB4_HUMANP53_HUMANBioGRID20858735 details
ERBB4_HUMANUBP8_HUMANBioGRID23153581 details
ERBB4_HUMANCBL_HUMANBioGRID25140053 details
ERBB4_HUMANAP2A_HUMANBioGRID20943952 details
ERBB4_HUMANESR1_HUMANBioGRID19439407 details
ERBB4_HUMANVANG1_HUMANBioGRID27648936 details
ERBB4_HUMANXPO1_HUMANBioGRID28974580 details
ERBB4_HUMANMAGI2_HUMANBioGRID17579610 details
ERBB4_HUMANKALRN_HUMANBioGRID21483438 details
ERBB4_HUMANBTC_HUMANHPRD11254912 details
ERBB4_HUMANADA17_HUMANHPRD15534001 details
ERBB4_HUMANNRG4_HUMANHPRD10348342 details
ERBB4_HUMANNRG3_HUMANHPRD9275162 details
ERBB4_HUMANTGFA_HUMANHPRD10918572 details
ERBB4_HUMANCCN2_HUMANHPRD12297288 details