Entity Details

Primary name MAG
Entity type gene
Source Source Link

Details

PrimaryID4099
RefseqGeneNG_034078
SymbolMAG
Namemyelin associated glycoprotein
Chromosome19
Location19q13.12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1989-05-11
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMAG_HUMAN

GO terms

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GOName
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007155 cell adhesion
GO:0010977 negative regulation of neuron projection development
GO:0019226 transmission of nerve impulse
GO:0019901 protein kinase binding
GO:0021762 substantia nigra development
GO:0022010 central nervous system myelination
GO:0030246 carbohydrate binding
GO:0030517 negative regulation of axon extension
GO:0031103 axon regeneration
GO:0031643 positive regulation of myelination
GO:0033270 paranode region of axon
GO:0033691 sialic acid binding
GO:0035749 myelin sheath adaxonal region
GO:0042803 protein homodimerization activity
GO:0043209 myelin sheath
GO:0043218 compact myelin
GO:0043220 Schmidt-Lanterman incisure
GO:0043524 negative regulation of neuron apoptotic process
GO:0045121 membrane raft
GO:0045665 negative regulation of neuron differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0050771 negative regulation of axonogenesis
GO:0050900 leukocyte migration
GO:0071260 cellular response to mechanical stimulus
GO:0097453 mesaxon
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:1905576 ganglioside GT1b binding

Diseases

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Disease IDSourceNameDescription
616680 OMIMSpastic paraplegia 75, autosomal recessive (SPG75)A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG75 is characterized by onset in early childhood and is associated with mild to moderate cognitive impairment. The disease is caused by variants affecting the gene represented in this entry.