Entity Details

Primary name MAPK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16644
EntryNameMAPK3_HUMAN
FullNameMAP kinase-activated protein kinase 3
TaxID9606
Evidenceevidence at protein level
Length382
SequenceStatuscomplete
DateCreated2005-12-06
DateModified2021-06-02

Ontological Relatives

GenesMAPKAPK3

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002224 toll-like receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine
GO:0035556 intracellular signal transduction
GO:0044351 macropinocytosis
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0051019 mitogen-activated protein kinase binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR027442 MAP kinase activated protein kinase, C-terminalFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617111 OMIMMacular dystrophy, patterned, 3 (MDPT3)A form of retinal patterned dystrophy, characterized by retinal pigment epithelium and Bruch's membrane changes resembling a 'dry desert land'. It begins around the age of 30 and progresses to retinitis pigmentosa. MDPT3 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB07728 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONEDrugbanksmall molecule
DB08358 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONEDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
MAPK3_HUMANMK11_HUMANBioGRID, IntAct21988832 23602568 26186194 28514442 details
MAPK3_HUMANHSPB1_HUMANBioGRID, HPRD, IntAct, Molecular Connections21575178 25241761 8774846 details
MAPK3_HUMANCSN6_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANEZH2_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANIGHM_HUMANMINT21900206 details
MAPK3_HUMANRAB2A_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANSPSY_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANSUMO3_HUMANBioGRID, MINT21900206 details
MAPK3_HUMANMK14_HUMANBioGRID, HPRD, IntAct11157753 15331440 23455922 23602568 25241761 25852190 26186194 26496610 28514442 31515488 31980649 details
MAPK3_HUMANAURKA_HUMANMINT24412244 details
MAPK3_HUMANBRAF_HUMANMINT24412244 details
MAPK3_HUMANBUB1_HUMANMINT24412244 details
MAPK3_HUMANCADH1_HUMANMINT24412244 details
MAPK3_HUMANARF_HUMANMINT24412244 details
MAPK3_HUMANDCC_HUMANMINT24412244 details
MAPK3_HUMANRHG07_HUMANMINT24412244 details
MAPK3_HUMANEGFR_HUMANMINT24412244 details
MAPK3_HUMANFBXW7_HUMANMINT24412244 details
MAPK3_HUMANRASN_HUMANMINT24412244 details
MAPK3_HUMANPGFRL_HUMANMINT24412244 details
MAPK3_HUMANRB_HUMANMINT24412244 details
MAPK3_HUMANSRC_HUMANMINT24412244 details
MAPK3_HUMANSTK11_HUMANMINT24412244 details
MAPK3_HUMANTFE2_HUMANBioGRID, HPRD10781029 details
MAPK3_HUMANNEDD4_HUMANBioGRID19953087 details
MAPK3_HUMANNED4L_HUMANBioGRID19953087 details
MAPK3_HUMANPHC2_HUMANBioGRID15563468 details
MAPK3_HUMANA4_HUMANBioGRID21832049 details
MAPK3_HUMANSRPK2_HUMANBioGRID26167880 details
MAPK3_HUMANATF1_HUMANBioGRID11335727 details
MAPK3_HUMANP52K_HUMANBioGRID20484669 details
MAPK3_HUMANCPZIP_HUMANBioGRID15850461 details
MAPK3_HUMANBECN1_HUMANBioGRID25693418 details
MAPK3_HUMANMK13_HUMANBioGRID, HPRD, IntAct25241761 9207191 details
MAPK3_HUMANBMI1_HUMANBioGRID15563468 details
MAPK3_HUMANRING2_HUMANBioGRID15563468 details
MAPK3_HUMANEF2K_HUMANHPRD12171600 details
MAPK3_HUMANEF2_HUMANHPRD12171600 details