Entity Details

Primary name SCN4B
Entity type gene
Source Source Link

Details

PrimaryID6330
RefseqGeneNG_011710
SymbolSCN4B
Namesodium voltage-gated channel beta subunit 4
Chromosome11
Location11q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-07-23
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsSCN4B_HUMAN

GO terms

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GOName
GO:0001518 voltage-gated sodium channel complex
GO:0005244 voltage-gated ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0006814 sodium ion transport
GO:0010765 positive regulation of sodium ion transport
GO:0014704 intercalated disc
GO:0017080 sodium channel regulator activity
GO:0031226 intrinsic component of plasma membrane
GO:0035725 sodium ion transmembrane transport
GO:0044325 transmembrane transporter binding
GO:0060048 cardiac muscle contraction
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086016 AV node cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:2000649 regulation of sodium ion transmembrane transporter activity

Diseases

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Disease IDSourceNameDescription
611819 OMIMLong QT syndrome 10 (LQT10)A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. The disease is caused by variants affecting the gene represented in this entry.
611819 OMIMLong QT syndrome 10 (LQT10)A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
SCN4BYIF1ABioGRID, IntAct32296183 details
SCN4BSCN1ABioGRID19228957 details
SCN4BSCN1BBioGRID19228957 details
SCN4BSCN2AHPRD12930796 details