Entity Details - PICKLE: A Protein InteraCtion KnowLedgebasE

UniProt IDs

NKX26_HUMAN

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GO	Name
GO:0000785	chromatin
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700	DNA-binding transcription factor activity
GO:0005634	nucleus
GO:0006357	regulation of transcription by RNA polymerase II
GO:0008284	positive regulation of cell population proliferation
GO:0021854	hypothalamus development
GO:0030154	cell differentiation
GO:0035050	embryonic heart tube development
GO:0043066	negative regulation of apoptotic process
GO:0043586	tongue development
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0048565	digestive tract development
GO:0055014	atrial cardiac muscle cell development
GO:0055015	ventricular cardiac muscle cell development
GO:0060037	pharyngeal system development
GO:0060039	pericardium development

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Disease ID	Source	Name	Description
217095	OMIM	Conotruncal heart malformations (CTHM)	A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. The disease may be caused by variants affecting the gene represented in this entry.

1 interaction

Interactor	Partner	Sources	Publications	Link
NKX2-6	RPS9	BioGRID, IntAct	30021884	details