Entity Details

Primary name GRP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IV61
EntryNameGRP3_HUMAN
FullNameRas guanyl-releasing protein 3
TaxID9606
Evidenceevidence at protein level
Length690
SequenceStatuscomplete
DateCreated2003-08-29
DateModified2021-06-02

Ontological Relatives

GenesRASGRP3

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0019900 kinase binding
GO:0019992 diacylglycerol binding
GO:0031267 small GTPase binding
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0048471 perinuclear region of cytoplasm

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR029645 Ras guanyl-releasing protein 3FamilyFamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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