Entity Details

Primary name ORML3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N138
EntryNameORML3_HUMAN
FullNameORM1-like protein 3
TaxID9606
Evidenceevidence at protein level
Length153
SequenceStatuscomplete
DateCreated2005-11-08
DateModified2021-06-02

Ontological Relatives

GenesORMDL3

GO terms

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GOName
GO:0002903 negative regulation of B cell apoptotic process
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006672 ceramide metabolic process
GO:0006686 sphingomyelin biosynthetic process
GO:0006940 regulation of smooth muscle contraction
GO:0010508 positive regulation of autophagy
GO:0016021 integral component of membrane
GO:0030667 secretory granule membrane
GO:0035339 SPOTS complex
GO:0035579 specific granule membrane
GO:0042552 myelination
GO:0043312 neutrophil degranulation
GO:0061744 motor behavior
GO:0090156 cellular sphingolipid homeostasis
GO:1900060 negative regulation of ceramide biosynthetic process
GO:1900182 positive regulation of protein localization to nucleus
GO:1904221 negative regulation of serine C-palmitoyltransferase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR007203 ORMDL familyFamilyFamily
IPR029883 ORM1-like protein 3FamilyFamily

Diseases

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Disease IDSourceNameDescription
600807 OMIMAsthma (ASTHMA)The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
ORML3_HUMANEF1A1_HUMANBioGRID, HPRD, IntAct16169070 details
ORML3_HUMANGP101_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANAR13B_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANSL7A1_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANGP152_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANSYT2_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANDHB13_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANCJ067_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANGET1_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANIF3M_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANLERL1_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANTM237_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANRETR3_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANRNF5_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANCOQ8A_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANEBP_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANF209A_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANNTCP_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANROM1_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANCERS3_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANKCNK5_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANREEP2_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
ORML3_HUMANLNX1_HUMANBioGRID22889411 details
ORML3_HUMANA4_HUMANBioGRID21832049 details
ORML3_HUMANPTN11_HUMANBioGRID27229929 details
ORML3_HUMANLMNA_HUMANBioGRID24623722 details
ORML3_HUMANSPTC1_HUMANBioGRID, DIP20182505 details
ORML3_HUMANSYVN1_HUMANBioGRID31477895 details