Entity Details

Primary name PURA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N142
EntryNamePURA1_HUMAN
FullNameAdenylosuccinate synthetase isozyme 1
TaxID9606
Evidenceevidence at protein level
Length457
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesADSS1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0002376 immune system process
GO:0003924 GTPase activity
GO:0004019 adenylosuccinate synthase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006167 AMP biosynthetic process
GO:0006531 aspartate metabolic process
GO:0006541 glutamine metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0014850 response to muscle activity
GO:0035690 cellular response to drug
GO:0042301 phosphate ion binding
GO:0042594 response to starvation
GO:0042802 identical protein binding
GO:0044208 'de novo' AMP biosynthetic process
GO:0046040 IMP metabolic process
GO:0051015 actin filament binding
GO:0071257 cellular response to electrical stimulus

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001114 Adenylosuccinate synthetaseFamilyFamily
IPR018220 Adenylosuccinate synthase, GTP-binding siteSiteBinding site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027509 Adenylosuccinate synthetase isozyme 1, chordatesFamilyFamily
IPR033128 Adenylosuccinate synthase, active siteSiteActive site
IPR042109 Adenylosuccinate synthetase, domain 1FamilyHomologous superfamily
IPR042110 Adenylosuccinate synthetase, domain 2FamilyHomologous superfamily
IPR042111 Adenylosuccinate synthetase, domain 3FamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00128 Aspartic acidDrugbanksmall molecule
DB00787 AcyclovirDrugbanksmall molecule
DB02109 HadacidinDrugbanksmall molecule
DB03510 6-O-Phosphoryl Inosine MonophosphateDrugbanksmall molecule
DB04137 Guanosine-5'-TriphosphateDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB04418 Adenylosuccinic acidDrugbanksmall molecule
DB04566 Inosinic AcidDrugbanksmall molecule
DB05540 AlanosineDrugbanksmall molecule

Interactions

5 interactions