Entity Details

Primary name DVL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14641
EntryNameDVL2_HUMAN
FullNameSegment polarity protein dishevelled homolog DVL-2
TaxID9606
Evidenceevidence at protein level
Length736
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDVL2

GO terms

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GOName
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0003151 outflow tract morphogenesis
GO:0005109 frizzled binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0007379 segment specification
GO:0007507 heart development
GO:0016235 aggresome
GO:0016328 lateral plasma membrane
GO:0016604 nuclear body
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0022007 convergent extension involved in neural plate elongation
GO:0030674 protein-macromolecule adaptor activity
GO:0031267 small GTPase binding
GO:0031343 positive regulation of cell killing
GO:0031410 cytoplasmic vesicle
GO:0034613 cellular protein localization
GO:0035329 hippo signaling
GO:0035567 non-canonical Wnt signaling pathway
GO:0042802 identical protein binding
GO:0043507 positive regulation of JUN kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0043621 protein self-association
GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045177 apical part of cell
GO:0045334 clathrin-coated endocytic vesicle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061024 membrane organization
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0150012 positive regulation of neuron projection arborization
GO:1904886 beta-catenin destruction complex disassembly

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000591 DEP domainDomainDomain
IPR001158 DIX domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR003351 Dishevelled protein domainDomainDomain
IPR008339 Dishevelled familyFamilyFamily
IPR008341 Dishevelled-2FamilyFamily
IPR015506 Dishevelled-related proteinFamilyFamily
IPR024580 Dishevelled C-terminalDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

147 interactions

InteractorPartnerSourcesPublicationsLink
DVL2_HUMANDVL2_HUMANBioGRID, HPRD, IntAct16189514 27107012 details
DVL2_HUMANZN165_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
DVL2_HUMANPHS_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANUBP5_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANPOLI_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
DVL2_HUMANCCD33_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANDPPA2_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANAP2M1_HUMANBioGRID, HPRD, IntAct16189514 31340145 31515488 details
DVL2_HUMANMCRS1_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANARG39_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANARRC_HUMANBioGRID, HPRD, IntAct, MINT16189514 21516116 details
DVL2_HUMANU2AF2_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANTIFA_HUMANBioGRID, HPRD, IntAct16189514 27107012 details
DVL2_HUMANELOA2_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
DVL2_HUMANDDI1_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANRNPS1_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANCPSF7_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANSNF8_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANSNIP1_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
DVL2_HUMANZBT8A_HUMANBioGRID, IntAct16189514 details
DVL2_HUMANKC1E_HUMANBioGRID, HPRD, IntAct16189514 23455922 31340145 31515488 details
DVL2_HUMANPRPF3_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANBAHD1_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANP53_HUMANBioGRID, HPRD, IntAct16189514 16713569 27107012 31515488 details
DVL2_HUMANBAG3_HUMANBioGRID, HPRD, IntAct, MINT16189514 21516116 31340145 details
DVL2_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
DVL2_HUMANZN263_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANRBPMS_HUMANBioGRID, HPRD, IntAct16189514 27107012 details
DVL2_HUMANENKD1_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANOTUL_HUMANBioGRID, HPRD, IntAct16189514 23708998 details
DVL2_HUMANAP1M1_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANVINEX_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANRHXF2_HUMANBioGRID, HPRD, IntAct16189514 details
DVL2_HUMANZN250_HUMANBioGRID, HPRD, IntAct16189514 27107012 details
DVL2_HUMANTHAP1_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
DVL2_HUMANRFOX1_HUMANBioGRID, HPRD, IntAct16713569 details
DVL2_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
DVL2_HUMANZGPAT_HUMANBioGRID, IntAct, MINT21516116 27107012 details
DVL2_HUMANRUSC1_HUMANBioGRID, MINT21516116 details
DVL2_HUMANEIF1B_HUMANBioGRID, MINT21516116 details
DVL2_HUMANWASP_HUMANBioGRID, MINT21516116 details
DVL2_HUMANUIMC1_HUMANBioGRID, IntAct, MINT21516116 29892012 31515488 details
DVL2_HUMANUBAC1_HUMANBioGRID, MINT21516116 details
DVL2_HUMANYES_HUMANBioGRID, MINT21516116 details
DVL2_HUMANMGN2_HUMANBioGRID, MINT21516116 details
DVL2_HUMANTZAP_HUMANBioGRID, MINT21516116 details
DVL2_HUMANTPM3_HUMANBioGRID, MINT21516116 details
DVL2_HUMANCTBP2_HUMANBioGRID, IntAct21988832 details
DVL2_HUMANPG12A_HUMANBioGRID, IntAct21988832 details
DVL2_HUMANWWOX_HUMANBioGRID, IntAct24550385 25678599 28514442 30619736 details
DVL2_HUMANAXIN1_HUMANBioGRID, DIP, HPRD, MINT10829020 21245303 22773187 23892894 29659741 details
DVL2_HUMANLRRK2_HUMANBioGRID, IntAct19625296 31046837 details
DVL2_HUMANADIP_HUMANBioGRID, IntAct26638075 27107012 details
DVL2_HUMANIHO1_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANPP16B_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANGRB2_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANZN410_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANGOGA2_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANTAB1_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANZN581_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANDCNL1_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANCARD9_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANPRP31_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANGRAP2_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANPSMF1_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANLMO3_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANSCNM1_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANBYST_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANHIP1_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANF161A_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANTLE5_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANN62CL_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANWT1_HUMANBioGRID, IntAct27107012 27229929 details
DVL2_HUMANBCL6_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANF90A1_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANTYDP2_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANKLH12_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANBEND7_HUMANBioGRID, IntAct27107012 details
DVL2_HUMANRIPK4_HUMANDIP23371553 details
DVL2_HUMANCLAT_HUMANIntAct32814053 details
DVL2_HUMANFGFR3_HUMANIntAct32814053 details
DVL2_HUMANRASH_HUMANIntAct32814053 details
DVL2_HUMANDAB2_HUMANBioGRID12805222 details
DVL2_HUMANARRB1_HUMANBioGRID, HPRD11742073 details
DVL2_HUMANMLP3A_HUMANBioGRID20639871 details
DVL2_HUMANGBRAP_HUMANBioGRID20639871 details
DVL2_HUMANVHL_HUMANBioGRID20639871 25825496 details
DVL2_HUMANNHLC1_HUMANBioGRID22223637 details
DVL2_HUMANITCH_HUMANBioGRID22826439 26701932 details
DVL2_HUMANGBRL1_HUMANBioGRID21691068 details
DVL2_HUMANRN185_HUMANBioGRID24727453 details
DVL2_HUMANDYLT1_HUMANBioGRID, HPRD10644691 26638075 details
DVL2_HUMANAAPK1_HUMANBioGRID21516116 details
DVL2_HUMANNOL12_HUMANBioGRID21516116 details
DVL2_HUMANWWP1_HUMANBioGRID26701932 31340145 details
DVL2_HUMANWWP2_HUMANBioGRID25071155 26701932 31048545 31340145 details
DVL2_HUMANABL1_HUMANBioGRID27229929 details
DVL2_HUMANAKAP9_HUMANBioGRID27107012 details
DVL2_HUMANUSP9X_HUMANBioGRID31340145 details
DVL2_HUMANVANG1_HUMANBioGRID, HPRD15456783 31340145 details
DVL2_HUMANPPM1A_HUMANHPRD10644691 details
DVL2_HUMANPRIC1_HUMANIntAct19379695 details
DVL2_HUMANSMUF1_HUMANHPRD, IntAct19379695 details
DVL2_HUMANPAR6A_HUMANHPRD, IntAct19379695 details
DVL2_HUMANTRI29_HUMANBioGRID, IntAct19249679 24469230 details
DVL2_HUMANAPC_HUMANBioGRID, IntAct, MINT20224554 26496610 details
DVL2_HUMANDVL1_HUMANBioGRID, MINT20224554 24643799 26186194 28514442 31340145 details
DVL2_HUMANDIXC1_HUMANMINT20823832 details
DVL2_HUMANDACT1_HUMANBioGRID, UniProt16446366 21262972 25558878 details
DVL2_HUMANPLK1_HUMANBioGRID, MINT22609948 25659891 31340145 details
DVL2_HUMANTAZ_HUMANbhf-ucl20412773 details
DVL2_HUMANWWTR1_HUMANbhf-ucl, BioGRID20412773 details
DVL2_HUMANBAMBI_HUMANbhf-ucl18838381 details
DVL2_HUMANDVL3_HUMANBioGRID, IntAct24643799 28514442 31340145 details
DVL2_HUMANDVLP1_HUMANIntAct28514442 details
DVL2_HUMANSIR1_HUMANBioGRID, DIP20439735 details
DVL2_HUMANCSK21_HUMANBioGRID10806215 31340145 details
DVL2_HUMANCTNB1_HUMANBioGRID10806215 details
DVL2_HUMANM3K1_HUMANBioGRID10829020 details
DVL2_HUMANSQSTM_HUMANBioGRID21691068 24616100 31340145 details
DVL2_HUMANIRS1_HUMANBioGRID24616100 details
DVL2_HUMANIRS2_HUMANBioGRID24616100 details
DVL2_HUMANIQGA1_HUMANBioGRID24639526 details
DVL2_HUMANNUMA1_HUMANBioGRID24469800 details
DVL2_HUMANZNRF3_HUMANBioGRID25891077 details
DVL2_HUMANRNF43_HUMANBioGRID25825523 25891077 32103169 details
DVL2_HUMANZBT17_HUMANBioGRID25558878 details
DVL2_HUMANFZD5_HUMANBioGRID25825523 details
DVL2_HUMANBAKOR_HUMANBioGRID25825496 details
DVL2_HUMANPI3R4_HUMANBioGRID25825496 details
DVL2_HUMANA16L1_HUMANBioGRID25825496 29634390 details
DVL2_HUMANEPN1_HUMANBioGRID25871009 details
DVL2_HUMANCUL3_HUMANBioGRID27477274 details
DVL2_HUMANRNF41_HUMANBioGRID27648936 details
DVL2_HUMANSMUF2_HUMANBioGRID29659741 details
DVL2_HUMANLMBRL_HUMANBioGRID31073040 details
DVL2_HUMANAP2A1_HUMANBioGRID31340145 details
DVL2_HUMANTNR6C_HUMANBioGRID29395067 details
DVL2_HUMANARRB2_HUMANHPRD12958364 details
DVL2_HUMANRHOA_HUMANHPRD12533515 details
DVL2_HUMANKPCA_HUMANHPRD12958364 details
DVL2_HUMANKPCB_HUMANHPRD12958364 details
DVL2_HUMANKPCG_HUMANHPRD12958364 details
DVL2_HUMANRUNX2_HUMANHPRD15262978 details
DVL2_HUMANRAC1_HUMANHPRD12533515 details
DVL2_HUMANFZD4_HUMANHPRD12958364 details
DVL2_HUMANDAAM1_HUMANHPRD11779461 details