Entity Details

Primary name ARHG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92974
EntryNameARHG2_HUMAN
FullNameRho guanine nucleotide exchange factor 2
TaxID9606
Evidenceevidence at protein level
Length986
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesARHGEF2

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005923 bicellular tight junction
GO:0005925 focal adhesion
GO:0006886 intracellular protein transport
GO:0007015 actin filament organization
GO:0007026 negative regulation of microtubule depolymerization
GO:0007049 cell cycle
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008017 microtubule binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0031267 small GTPase binding
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0032587 ruffle membrane
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell population proliferation
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0055059 asymmetric neuroblast division
GO:0060546 negative regulation of necroptotic process
GO:0071225 cellular response to muramyl dipeptide
GO:0071356 cellular response to tumor necrosis factor
GO:0071474 cellular hyperosmotic response
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:2001224 positive regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR037806 ARHGEF2, PH domainDomainDomain
IPR041020 ARHGEF1-like, PH domainDomainDomain

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
ARHG2_HUMANMARK2_HUMANBioGRID, IntAct19615732 21513698 22072711 29089450 details
ARHG2_HUMANRP25L_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ARHG2_HUMANRHOA_HUMANBioGRID, HPRD, IntAct22072711 28514442 32296183 9857026 details
ARHG2_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
ARHG2_HUMAN1433T_HUMANBioGRID, IntAct14970201 28514442 29089450 details
ARHG2_HUMANPAK1_HUMANBioGRID, HPRD14970201 details
ARHG2_HUMANRAC1_HUMANBioGRID, HPRD11595749 9857026 details
ARHG2_HUMANMARK3_HUMANBioGRID29089450 details
ARHG2_HUMANDYLT1_HUMANBioGRID29089450 details
ARHG2_HUMANPTPRF_HUMANBioGRID25458010 details
ARHG2_HUMANIKBE_HUMANIntAct14743216 details
ARHG2_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
ARHG2_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT14970201 15161933 22072711 28514442 details
ARHG2_HUMANPAK4_HUMANBioGRID, MINT22653441 29089450 details
ARHG2_HUMANPPP6_HUMANBioGRID, IntAct24255178 27684187 27880917 29089450 details
ARHG2_HUMANANR28_HUMANBioGRID, IntAct24255178 29089450 details
ARHG2_HUMANPP6R1_HUMANBioGRID, IntAct24255178 29089450 details
ARHG2_HUMANKSR1_HUMANIntAct24525234 details
ARHG2_HUMANPLCG1_HUMANBioGRID19805522 details
ARHG2_HUMANMK01_HUMANBioGRID18211802 details
ARHG2_HUMANUBP21_HUMANBioGRID22298430 details
ARHG2_HUMANASAP1_HUMANBioGRID21352810 details
ARHG2_HUMANPP6R3_HUMANBioGRID29089450 details
ARHG2_HUMANPP6R2_HUMANBioGRID29089450 details
ARHG2_HUMANPAXI_HUMANBioGRID24706358 details
ARHG2_HUMANTULP3_HUMANBioGRID33187986 details
ARHG2_HUMANRRAS2_HUMANHPRD12384139 details
ARHG2_HUMAN1433E_HUMANHPRD14970201 details
ARHG2_HUMANCING_HUMANHPRD15866167 details