Entity Details

Primary name P5CR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96C36
EntryNameP5CR2_HUMAN
FullNamePyrroline-5-carboxylate reductase 2
TaxID9606
Evidenceevidence at protein level
Length320
SequenceStatuscomplete
DateCreated2005-03-01
DateModified2021-06-02

Ontological Relatives

GenesPYCR2

GO terms

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GOName
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006561 proline biosynthetic process
GO:0009064 glutamine family amino acid metabolic process
GO:0034599 cellular response to oxidative stress
GO:0055129 L-proline biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR000304 Pyrroline-5-carboxylate reductaseFamilyFamily
IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminalDomainDomain
IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domainDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00172 ProlineDrugbanksmall molecule