Entity Details

Primary name CIB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99828
EntryNameCIB1_HUMAN
FullNameCalcium and integrin-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length191
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCIB1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002931 response to ischemia
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0006302 double-strand break repair
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007026 negative regulation of microtubule depolymerization
GO:0007113 endomitotic cell cycle
GO:0007155 cell adhesion
GO:0007286 spermatid development
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008427 calcium-dependent protein kinase inhibitor activity
GO:0010977 negative regulation of neuron projection development
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030220 platelet formation
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031122 cytoplasmic microtubule organization
GO:0031267 small GTPase binding
GO:0031982 vesicle
GO:0032433 filopodium tip
GO:0032587 ruffle membrane
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0038163 thrombopoietin-mediated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043204 perikaryon
GO:0043495 protein-membrane adaptor activity
GO:0044325 transmembrane transporter binding
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0048471 perinuclear region of cytoplasm
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051301 cell division
GO:0051302 regulation of cell division
GO:0051898 negative regulation of protein kinase B signaling
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0071944 cell periphery
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090314 positive regulation of protein targeting to membrane
GO:0097191 extrinsic apoptotic signaling pathway
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000256 positive regulation of male germ cell proliferation

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Cell projection
Cytoplasm
Golgi apparatus
Membrane
Nucleus
Perikaryon

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site

Diseases

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Disease IDSourceNameDescription
618267 OMIMEpidermodysplasia verruciformis 3 (EV3)A form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. EV3 inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule

Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
CIB1_HUMANPSN2_HUMANBioGRID, HPRD, MINT10366599 details
CIB1_HUMANEXOSX_HUMANBioGRID, HPRD, IntAct15231747 details
CIB1_HUMANWASL_HUMANMINT16582881 details
CIB1_HUMANCDK4_HUMANBioGRID, IntAct21988832 details
CIB1_HUMANAURKB_HUMANBioGRID, IntAct21988832 details
CIB1_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
CIB1_HUMANIF4G1_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANTMM95_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANCEAM6_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANCALCB_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANNCK2_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANGLIS3_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANCD27_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANSFR19_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANT10IP_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANNDKM_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANONEC3_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANLSS_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANPAX7_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANSSX7_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANZBT49_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANELAP1_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANFUCO_HUMANBioGRID, IntAct32296183 details
CIB1_HUMANM3K5_HUMANBioGRID, DIP19805025 details
CIB1_HUMANICAM1_HUMANIntAct32814053 details
CIB1_HUMAN1433G_HUMANIntAct32814053 details
CIB1_HUMANSETB1_HUMANIntAct32814053 details
CIB1_HUMANKAT5_HUMANIntAct32814053 details
CIB1_HUMANLMO3_HUMANIntAct32814053 details
CIB1_HUMANSPRE1_HUMANIntAct32814053 details
CIB1_HUMANPLK2_HUMANBioGRID, HPRD10523297 12651910 details
CIB1_HUMANPLK3_HUMANBioGRID, HPRD10523297 11039900 details
CIB1_HUMANRAC3_HUMANBioGRID, HPRD11756406 details
CIB1_HUMANUBR5_HUMANBioGRID, HPRD12011095 details
CIB1_HUMANNBR1_HUMANBioGRID11856312 details
CIB1_HUMANPSN1_HUMANBioGRID, HPRD10366599 details
CIB1_HUMANPRKDC_HUMANBioGRID, HPRD15190070 9372844 details
CIB1_HUMANNRIP1_HUMANBioGRID15604093 details
CIB1_HUMANTERT_HUMANBioGRID, HPRD15190070 20959453 details
CIB1_HUMANITA2B_HUMANBioGRID, HPRD24163826 9030514 details
CIB1_HUMANCASP2_HUMANBioGRID10745097 details
CIB1_HUMANFEZ1_HUMANHPRD11856312 details
CIB1_HUMANPAX3_HUMANHPRD11997098 details
CIB1_HUMANIFI6_HUMANHPRD15685448 details
CIB1_HUMANWASP_HUMANHPRD16582881 details
CIB1_HUMANITA2_HUMANMINT16582881 details
CIB1_HUMANPAK1_HUMANmbinfo16061695 details
CIB1_HUMANFAK1_HUMANBioGRID12881299 details
CIB1_HUMANITB3_HUMANBioGRID24163826 details
CIB1_HUMANITA5_HUMANBioGRID24163826 details