Entity Details

Primary name SMAD7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15105
EntryNameSMAD7_HUMAN
FullNameMothers against decapentaplegic homolog 7
TaxID9606
Evidenceevidence at protein level
Length426
SequenceStatuscomplete
DateCreated2001-05-04
DateModified2021-06-02

Ontological Relatives

GenesSMAD7

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0001650 fibrillar center
GO:0001657 ureteric bud development
GO:0002725 negative regulation of T cell cytokine production
GO:0003677 DNA binding
GO:0005518 collagen binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008013 beta-catenin binding
GO:0009653 anatomical structure morphogenesis
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0016579 protein deubiquitination
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925 regulation of activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034333 adherens junction assembly
GO:0034616 response to laminar fluid shear stress
GO:0034629 cellular protein-containing complex localization
GO:0034713 type I transforming growth factor beta receptor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048185 activin binding
GO:0048844 artery morphogenesis
GO:0050821 protein stabilization
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055117 regulation of cardiac muscle contraction
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0070411 I-SMAD binding
GO:0071144 heteromeric SMAD protein complex
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0140416 transcription regulator inhibitor activity
GO:1902731 negative regulation of chondrocyte proliferation
GO:1903043 positive regulation of chondrocyte hypertrophy
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000317 negative regulation of T-helper 17 type immune response
GO:2000320 negative regulation of T-helper 17 cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
612229 OMIMColorectal cancer 3 (CRCS3)A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
SMAD7_HUMANSMUF2_HUMANBioGRID, DIP, HPRD, MINT11163210 14722617 15221015 15231748 16061177 16641086 17719543 18448069 20937913 22624557 22773947 22921829 23973329 26435193 26679521 27292644 28292929 29235476 32283253 details
SMAD7_HUMANPIAS1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANPIAS4_HUMANBioGRID, HPRD, MINT12815042 15231748 details
SMAD7_HUMANXRCC6_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANKDM2A_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANHEYL_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANCXXC5_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANSOX7_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANZN107_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANTTF2_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANMYOD1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANSOX5_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANASH1L_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANZBT11_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANSOX13_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANMRTFB_HUMANBioGRID, MINT15231748 details
SMAD7_HUMANTTF1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANCSN5_HUMANBioGRID, IntAct14993265 details
SMAD7_HUMANWWP2_HUMANBioGRID, I2D21258410 22773947 31546607 details
SMAD7_HUMANSIR1_HUMANBioGRID, UniProt17098745 details
SMAD7_HUMANFKB1A_HUMANbhf-ucl, BioGRID16720724 details
SMAD7_HUMANYAP1_HUMANBioGRID, DIP, HPRD, MINT12118366 22921829 25283809 details
SMAD7_HUMANEP300_HUMANBioGRID, HPRD, IntAct12408818 25303530 details
SMAD7_HUMANSMAD4_HUMANBioGRID, IntAct15128733 15817471 17438144 19032343 26555259 details
SMAD7_HUMANSMUF1_HUMANBioGRID, DIP, HPRD11278251 12151385 12519765 14722617 15221015 16720724 20937913 22152476 22773947 22921829 23959799 24700460 27292644 details
SMAD7_HUMANNED4L_HUMANBioGRID, DIP22773947 22921829 details
SMAD7_HUMANTGFR1_HUMANBioGRID, HPRD10757800 11163210 12151385 14657019 14722617 15148321 15359284 15946939 16027725 17314099 19758997 20663871 21791611 22624557 23027871 25149540 31746425 9215638 9335507 details
SMAD7_HUMANRN111_HUMANBioGRID, HPRD14657019 23530056 27292644 details
SMAD7_HUMANDVL1_HUMANBioGRID, HPRD12650946 details
SMAD7_HUMANERBIN_HUMANBioGRID, HPRD12650946 details
SMAD7_HUMANSTABP_HUMANBioGRID, HPRD11483516 details
SMAD7_HUMANSMAD6_HUMANBioGRID, HPRD26555259 9256479 details
SMAD7_HUMANUCHL5_HUMANBioGRID16027725 details
SMAD7_HUMANHDAC1_HUMANBioGRID15831498 15831516 details
SMAD7_HUMANSMAD2_HUMANBioGRID17438144 26555259 details
SMAD7_HUMANZEB1_HUMANBioGRID20514018 details
SMAD7_HUMANUB2L3_HUMANBioGRID16061177 details
SMAD7_HUMANTGFI1_HUMANBioGRID18762808 details
SMAD7_HUMANPR15A_HUMANBioGRID14718519 details
SMAD7_HUMANCBL_HUMANBioGRID26055326 details
SMAD7_HUMANPARD3_HUMANBioGRID, HPRD12650946 details
SMAD7_HUMANAXIN2_HUMANBioGRID24584437 27292644 details
SMAD7_HUMANSMAD3_HUMANBioGRID26555259 details
SMAD7_HUMANSETD7_HUMANBioGRID27292644 details
SMAD7_HUMANOTUD1_HUMANBioGRID29235476 details
SMAD7_HUMANRNF12_HUMANBioGRID29235476 details
SMAD7_HUMANZBT44_HUMANHPRD15231748 details
SMAD7_HUMANMBD1_HUMANHPRD15231748 details
SMAD7_HUMANAXIN1_HUMANBioGRID, HPRD, MINT16601693 18593713 details
SMAD7_HUMANACV1B_HUMANbhf-ucl, BioGRID, HPRD12023024 16720724 20663871 details
SMAD7_HUMANHDAC3_HUMANBioGRID, IntAct15831498 15831516 19032343 details
SMAD7_HUMANRN165_HUMANDIP23610558 details
SMAD7_HUMANBMR1A_HUMANBioGRID15148321 20663871 details
SMAD7_HUMANCTNB1_HUMANBioGRID, HPRD15684397 18593713 details
SMAD7_HUMANLEF1_HUMANBioGRID15684397 15750622 details
SMAD7_HUMANMK14_HUMANBioGRID, HPRD12589052 17172861 details
SMAD7_HUMANMP2K3_HUMANBioGRID12589052 details
SMAD7_HUMANMP2K6_HUMANBioGRID, HPRD12589052 details
SMAD7_HUMANM3K7_HUMANBioGRID, HPRD12589052 details
SMAD7_HUMANTAB1_HUMANBioGRID, HPRD11737269 12589052 details
SMAD7_HUMANTGFR2_HUMANBioGRID, HPRD11163210 25149540 9335507 details
SMAD7_HUMANAKT1_HUMANBioGRID, HPRD16362038 details
SMAD7_HUMANSTRAP_HUMANBioGRID, HPRD10757800 17314099 details
SMAD7_HUMANKAT2B_HUMANBioGRID16285943 details
SMAD7_HUMANITCH_HUMANBioGRID15946939 22773947 28400336 details
SMAD7_HUMANHDAC2_HUMANBioGRID15831498 15831516 details
SMAD7_HUMANHDAC5_HUMANBioGRID15831498 15831516 details
SMAD7_HUMANHDAC6_HUMANBioGRID15831498 15831516 details
SMAD7_HUMANNEDD4_HUMANBioGRID15496141 22773947 details
SMAD7_HUMANSRF_HUMANBioGRID16690609 details
SMAD7_HUMANWWP1_HUMANBioGRID15221015 15359284 22773947 details
SMAD7_HUMANT22D1_HUMANBioGRID21791611 details
SMAD7_HUMANUBP11_HUMANBioGRID22773947 24850914 details
SMAD7_HUMANUBP15_HUMANBioGRID22344298 30980801 details
SMAD7_HUMANTAB2_HUMANBioGRID17384642 details
SMAD7_HUMANTAB3_HUMANBioGRID17384642 details
SMAD7_HUMANTOLIP_HUMANBioGRID23027871 details
SMAD7_HUMANP53_HUMANBioGRID17172861 details
SMAD7_HUMANATM_HUMANBioGRID17172861 details
SMAD7_HUMANBAMBI_HUMANBioGRID19758997 details
SMAD7_HUMANCADH1_HUMANBioGRID18593713 details
SMAD7_HUMANBMPR2_HUMANBioGRID20663871 details
SMAD7_HUMANACVR1_HUMANBioGRID20663871 details
SMAD7_HUMANAVR2B_HUMANBioGRID20663871 details
SMAD7_HUMANUBE2O_HUMANBioGRID23455153 details
SMAD7_HUMANMYC_HUMANBioGRID24259667 details
SMAD7_HUMANSKP2_HUMANBioGRID24259667 details
SMAD7_HUMANTF7L2_HUMANBioGRID15684397 details
SMAD7_HUMANNR4A1_HUMANBioGRID24584437 details
SMAD7_HUMANSMAD1_HUMANBioGRID26555259 details
SMAD7_HUMANSMAD9_HUMANBioGRID26555259 details
SMAD7_HUMANCYLD_HUMANBioGRID30315770 details
SMAD7_HUMANTBR1_HUMANBioGRID30980801 details
SMAD7_HUMANTRI37_HUMANBioGRID32916597 details
SMAD7_HUMANSMAD7_HUMANHPRD12589052 details
SMAD7_HUMANHAT1_HUMANHPRD12408818 details
SMAD7_HUMANSTALP_HUMANHPRD14728725 details
SMAD7_HUMANBMR1B_HUMANHPRD15761153 details
SMAD7_HUMANSASH3_HUMANHPRD15761153 details