Entity Details

Primary name AXIN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15169
EntryNameAXIN1_HUMAN
FullNameAxin-1
TaxID9606
Evidenceevidence at protein level
Length862
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesAXIN1

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007275 multicellular organism development
GO:0008013 beta-catenin binding
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0016055 Wnt signaling pathway
GO:0016328 lateral plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030111 regulation of Wnt signaling pathway
GO:0030159 signaling receptor complex adaptor activity
GO:0030877 beta-catenin destruction complex
GO:0031398 positive regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031625 ubiquitin protein ligase binding
GO:0032147 activation of protein kinase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034622 cellular protein-containing complex assembly
GO:0035591 signaling adaptor activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045732 positive regulation of protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0046332 SMAD binding
GO:0048471 perinuclear region of cytoplasm
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0060090 molecular adaptor activity
GO:0070016 armadillo repeat domain binding
GO:0070411 I-SMAD binding
GO:0071944 cell periphery
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1904885 beta-catenin destruction complex assembly
GO:1904886 beta-catenin destruction complex disassembly
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001158 DIX domainDomainDomain
IPR014936 Axin beta-catenin bindingDomainDomain
IPR016137 RGS domainDomainDomain
IPR024066 RGS, subdomain 1/3FamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR029797 Axin-1FamilyFamily
IPR032101 Axin-1/2, tankyrase-binding domainDomainDomain
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily
IPR043581 Axin-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB04447 1,4-DithiothreitolDrugbanksmall molecule

Interactions

129 interactions

InteractorPartnerSourcesPublicationsLink
AXIN1_HUMANDPYL1_HUMANBioGRID, HPRD, IntAct16169070 details
AXIN1_HUMANEF1A1_HUMANBioGRID, HPRD, IntAct16169070 details
AXIN1_HUMANAN32A_HUMANBioGRID, HPRD, IntAct16169070 details
AXIN1_HUMANAXIN1_HUMANBioGRID, DIP, HPRD, IntAct10811618 11884395 16169070 18632848 21245303 23892894 9920888 details
AXIN1_HUMANGAK_HUMANBioGRID, HPRD, IntAct16169070 details
AXIN1_HUMANUT14A_HUMANBioGRID, HPRD, IntAct16169070 details
AXIN1_HUMANSH3G1_HUMANHPRD, IntAct16169070 details
AXIN1_HUMANRN111_HUMANBioGRID, HPRD, MINT16601693 26871637 details
AXIN1_HUMANCTNB1_HUMANbhf-ucl, BioGRID, DIP, HPRD, I2D, IntAct, MINT10228155 10488109 12000790 12421363 12805222 16199882 16890161 17318191 17510365 18593713 18632848 19131971 19166851 19223551 20128690 20531388 21242974 22509369 22682247 22773187 23892894 23959799 24976009 26496610 27902311 29045831 29789528 30181396 32533114 34079125 9734785 details
AXIN1_HUMANGSK3B_HUMANbhf-ucl, BioGRID, DIP, HPRD, I2D, IntAct, MINT10228155 10481074 10488109 10581160 11738041 12511557 12584189 16199882 16293724 16890161 17318175 17318191 17510365 17601533 18593713 18632848 19131971 19202075 19303846 19759537 20128690 21242974 21502811 21988832 22270359 22509369 22613765 22682247 22773187 23455922 23602568 23892894 23959799 24451375 24976009 25241761 26496610 26912724 28546513 29045831 29568061 29789528 30181396 9482734 9734785 details
AXIN1_HUMAN2A5A_HUMANBioGRID, MINT11297546 19131971 details
AXIN1_HUMANMYC_HUMANBioGRID, MINT19131971 details
AXIN1_HUMANAPC_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT10228155 10811618 11297546 16199882 17510365 18786926 19131971 20128690 22682247 23277359 26496610 29045831 29713058 9734785 details
AXIN1_HUMANPML_HUMANBioGRID, I2D21057547 details
AXIN1_HUMANP53_HUMANBioGRID, I2D21057547 23826318 details
AXIN1_HUMANMYOTI_HUMANBioGRID, IntAct21988832 details
AXIN1_HUMANKC1E_HUMANBioGRID, HPRD, IntAct11487578 11884395 12000790 21988832 22682247 26496610 details
AXIN1_HUMANRBTN2_HUMANBioGRID, IntAct21988832 details
AXIN1_HUMANANM1_HUMANBioGRID, I2D21242974 details
AXIN1_HUMANTNKS2_HUMANBioGRID, IntAct22153077 31554794 details
AXIN1_HUMANLRP6_HUMANBioGRID, DIP, HPRD, IntAct12897152 16890161 19107203 20128690 22682247 23892894 23959799 24976009 28966723 details
AXIN1_HUMANAMER1_HUMANbhf-ucl, BioGRID, IntAct17510365 20128690 22682247 26496610 details
AXIN1_HUMANDVL2_HUMANBioGRID, DIP, HPRD, MINT10829020 21245303 22773187 23892894 29659741 details
AXIN1_HUMANPLAK_HUMANBioGRID, HPRD, IntAct10488109 26496610 26871637 details
AXIN1_HUMANTRI15_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANTRIM1_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANSUMO5_HUMANIntAct26871637 details
AXIN1_HUMANTRI27_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANTRI37_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANCACO2_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANPPIP1_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANTRIP6_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANKR412_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANSUMO1_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANMDFI_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANCARD9_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANK1C40_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANKRA42_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANTFP11_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANSCYL1_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANLHX4_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANGOGA2_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANZBT26_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANANCHR_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANSTX11_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANCCD57_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANTRAF2_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANMTUS2_HUMANBioGRID, IntAct26871637 details
AXIN1_HUMANUBP7_HUMANbhf-ucl, BioGRID17510365 29045831 31519875 details
AXIN1_HUMANSPRE1_HUMANIntAct32814053 details
AXIN1_HUMANDAB2_HUMANBioGRID, HPRD12805222 details
AXIN1_HUMANDVL1_HUMANBioGRID, HPRD10330403 10428961 12556519 18632848 9482734 details
AXIN1_HUMANDAXX_HUMANBioGRID17210684 details
AXIN1_HUMANCARM1_HUMANBioGRID21242974 details
AXIN1_HUMANSMUF2_HUMANBioGRID20858899 details
AXIN1_HUMANSMUF1_HUMANBioGRID23959799 24700460 details
AXIN1_HUMANGNAS3_HUMANBioGRID16293724 details
AXIN1_HUMANGNAS2_HUMANBioGRID16293724 details
AXIN1_HUMANALEX_HUMANBioGRID16293724 details
AXIN1_HUMANGNAS1_HUMANBioGRID16293724 details
AXIN1_HUMANTNKS1_HUMANBioGRID25547115 30472184 31554794 details
AXIN1_HUMANSIAH1_HUMANBioGRID26871637 28546513 details
AXIN1_HUMANMEOX2_HUMANBioGRID26871637 details
AXIN1_HUMANHOMEZ_HUMANBioGRID26871637 details
AXIN1_HUMANNUTM1_HUMANBioGRID26871637 details
AXIN1_HUMANKR103_HUMANBioGRID26871637 details
AXIN1_HUMANETV6_HUMANBioGRID26871637 details
AXIN1_HUMANNBR1_HUMANBioGRID26871637 details
AXIN1_HUMANASPP2_HUMANBioGRID26871637 details
AXIN1_HUMANENTR1_HUMANBioGRID26871637 details
AXIN1_HUMANCDA7L_HUMANBioGRID26871637 details
AXIN1_HUMANGMCL1_HUMANBioGRID26871637 details
AXIN1_HUMANTSG10_HUMANBioGRID26871637 details
AXIN1_HUMANTRI42_HUMANBioGRID26871637 details
AXIN1_HUMANLHX8_HUMANBioGRID26871637 details
AXIN1_HUMANPIAS1_HUMANHPRD12223491 details
AXIN1_HUMANSMAD7_HUMANBioGRID, HPRD, MINT16601693 18593713 details
AXIN1_HUMANPP1A_HUMANBioGRID, MINT17318175 details
AXIN1_HUMANGSK3A_HUMANbhf-ucl, BioGRID, IntAct, MINT17318175 17510365 19131971 23602568 23959799 26496610 26912724 27684187 details
AXIN1_HUMANPP2AA_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT17510365 19131971 22682247 9920888 details
AXIN1_HUMANNIN_HUMANMINT19390532 details
AXIN1_HUMANTBG1_HUMANMINT19390532 details
AXIN1_HUMANTRI29_HUMANIntAct19249679 details
AXIN1_HUMANAMMR1_HUMANMINT21304492 details
AXIN1_HUMANPPM1A_HUMANMINT10644691 details
AXIN1_HUMANDVL3_HUMANBioGRID, HPRD, IntAct12805222 20128690 22682247 details
AXIN1_HUMANKC1A_HUMANbhf-ucl, BioGRID, HPRD, IntAct11884395 17318175 17510365 22682247 26496610 details
AXIN1_HUMANAXIN2_HUMANBioGRID, IntAct20128690 22682247 details
AXIN1_HUMANM3K1_HUMANBioGRID, IntAct10829020 11884395 20128690 22682247 24135036 details
AXIN1_HUMANFBW1B_HUMANBioGRID, IntAct22682247 25332235 25900982 details
AXIN1_HUMANDACT1_HUMANUniProt22470507 details
AXIN1_HUMANYAP1_HUMANBioGRID, IntAct24976009 29789528 details
AXIN1_HUMANFBW1A_HUMANBioGRID, HPRD, IntAct10228155 22682247 24976009 25900982 29045831 29789528 details
AXIN1_HUMANTGIF1_HUMANIntAct25873176 details
AXIN1_HUMANWDR26_HUMANbhf-ucl, BioGRID, MINT17510365 27098453 details
AXIN1_HUMANUBC_HUMANbhf-ucl, BioGRID17510365 22682247 details
AXIN1_HUMANGID8_HUMANbhf-ucl, BioGRID17510365 28829046 details
AXIN1_HUMAN2A5G_HUMANbhf-ucl, HPRD10698523 17510365 details
AXIN1_HUMANARRB1_HUMANBioGRID, DIP19202075 details
AXIN1_HUMANDAB2P_HUMANDIP20080667 details
AXIN1_HUMANFXR1_HUMANMINT21653829 details
AXIN1_HUMANFXR2_HUMANMINT21653829 details
AXIN1_HUMANTSC1_HUMANBioGRID, MINT12511557 21653829 details
AXIN1_HUMANLRP5_HUMANBioGRID, HPRD11336703 18632848 18762581 details
AXIN1_HUMANTSC2_HUMANBioGRID12511557 details
AXIN1_HUMANSTRAP_HUMANBioGRID21502811 details
AXIN1_HUMANHIPK2_HUMANBioGRID21057547 23826318 details
AXIN1_HUMANHD_HUMANBioGRID20531388 details
AXIN1_HUMANSKI_HUMANBioGRID21795712 details
AXIN1_HUMANSKIL_HUMANBioGRID21795712 details
AXIN1_HUMANNCK2_HUMANBioGRID, HPRD11557983 details
AXIN1_HUMANCAV1_HUMANBioGRID16890161 details
AXIN1_HUMANTNAP3_HUMANBioGRID23671587 details
AXIN1_HUMANM3K4_HUMANBioGRID, HPRD15262978 17726008 details
AXIN1_HUMANM3K2_HUMANBioGRID26884171 details
AXIN1_HUMANUBP15_HUMANBioGRID26884171 details
AXIN1_HUMANFOXM1_HUMANBioGRID26912724 details
AXIN1_HUMANTRI65_HUMANBioGRID28754688 details
AXIN1_HUMANSP1_HUMANBioGRID30181396 details
AXIN1_HUMANMKRN1_HUMANBioGRID29713058 details
AXIN1_HUMANPRC1_HUMANBioGRID26941395 details
AXIN1_HUMANAAPK1_HUMANBioGRID31995728 details
AXIN1_HUMANUBP44_HUMANBioGRID32285989 details
AXIN1_HUMANSMAD2_HUMANHPRD11438668 details
AXIN1_HUMANSMAD3_HUMANHPRD11438668 details
AXIN1_HUMANSENP2_HUMANHPRD11997515 details
AXIN1_HUMAN2A5B_HUMANHPRD10698523 details
AXIN1_HUMANDIXC1_HUMANHPRD15262978 details
AXIN1_HUMANRUNX2_HUMANHPRD15262978 details