Entity Details - PICKLE: A Protein InteraCtion KnowLedgebasE

Primary name	S39A8_HUMAN
Entity type	UniProt
Source	Source Link

Details

Accession	Q9C0K1
EntryName	S39A8_HUMAN
FullName	Metal cation symporter ZIP8
TaxID	9606
Evidence	evidence at protein level
Length	460
SequenceStatus	complete
DateCreated	2007-12-04
DateModified	2021-06-02

Ontological Relatives

Genes

SLC39A8

GO terms

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GO	Name
GO:0005381	iron ion transmembrane transporter activity
GO:0005384	manganese ion transmembrane transporter activity
GO:0005385	zinc ion transmembrane transporter activity
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006487	protein N-linked glycosylation
GO:0006525	arginine metabolic process
GO:0006824	cobalt ion transport
GO:0006829	zinc ion transport
GO:0006876	cellular cadmium ion homeostasis
GO:0006882	cellular zinc ion homeostasis
GO:0015086	cadmium ion transmembrane transporter activity
GO:0015087	cobalt ion transmembrane transporter activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015296	anion:cation symporter activity
GO:0015701	bicarbonate transport
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030026	cellular manganese ion homeostasis
GO:0030198	extracellular matrix organization
GO:0031090	organelle membrane
GO:0042391	regulation of membrane potential
GO:0061757	leukocyte adhesion to arterial endothelial cell
GO:0070574	cadmium ion transmembrane transport
GO:0071421	manganese ion transmembrane transport
GO:0071577	zinc ion transmembrane transport
GO:0071578	zinc ion import across plasma membrane
GO:0097079	selenite:proton symporter activity
GO:0097080	plasma membrane selenite transport
GO:0098711	iron ion import across plasma membrane
GO:0140412	zinc:bicarbonate symporter activity
GO:1990079	cartilage homeostasis
GO:1990540	mitochondrial manganese ion transmembrane transport

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell membrane
Lysosome membrane

Domains

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Domain	Name	Category	Type
IPR003689	Zinc/iron permease	Family	Family

Diseases

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Disease ID	Source	Name	Description
616721	OMIM	Congenital disorder of glycosylation 2N (CDG2N)	A form of congenital disorder of glycosylation, a genetically heterogeneous group of autosomal recessive, multisystem disorders caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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Drug	Name	Source	Type
DB14533	Zinc chloride	Drugbank	small molecule
DB14548	Zinc sulfate, unspecified form	Drugbank	small molecule

Interactions

1 interaction

Interactor	Partner	Sources	Publications	Link
S39A8_HUMAN	PE2R4_HUMAN	BioGRID, MINT	28298427	details