Entity Details

Primary name PDGFD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9GZP0
EntryNamePDGFD_HUMAN
FullNamePlatelet-derived growth factor D
TaxID9606
Evidenceevidence at protein level
Length370
SequenceStatuscomplete
DateCreated2006-09-19
DateModified2021-06-02

Ontological Relatives

GenesPDGFD

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005161 platelet-derived growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0007275 multicellular organism development
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335 positive regulation of cell migration
GO:0031954 positive regulation of protein autophosphorylation
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0043406 positive regulation of MAP kinase activity
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048146 positive regulation of fibroblast proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0051781 positive regulation of cell division
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070851 growth factor receptor binding
GO:0071230 cellular response to amino acid stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071673 positive regulation of smooth muscle cell chemotaxis
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:2000439 positive regulation of monocyte extravasation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000072 PDGF/VEGF domainDomainDomain
IPR000859 CUB domainDomainDomain
IPR027123 Platelet-derived growth factor DFamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily
IPR035914 Spermadhesin, CUB domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05139 CR002Drugbankbiotech
DB05465 TandutinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PDGFD_HUMANPGFRB_HUMANHPRD14514732 details