Entity Details

Primary name PLK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H4B4
EntryNamePLK3_HUMAN
FullNameSerine/threonine-protein kinase PLK3
TaxID9606
Evidenceevidence at protein level
Length646
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesPLK3

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000278 mitotic cell cycle
GO:0000302 response to reactive oxygen species
GO:0000922 spindle pole
GO:0002039 p53 binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005813 centrosome
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006970 response to osmotic stress
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint signaling
GO:0007113 endomitotic cell cycle
GO:0009314 response to radiation
GO:0030425 dendrite
GO:0031122 cytoplasmic microtubule organization
GO:0032465 regulation of cytokinesis
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043491 protein kinase B signaling
GO:0044819 mitotic G1/S transition checkpoint signaling
GO:0051302 regulation of cell division
GO:0090166 Golgi disassembly
GO:0090316 positive regulation of intracellular protein transport
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904716 positive regulation of chaperone-mediated autophagy
GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000959 POLO box domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020658 Serine/threonine-protein kinase Plk3FamilyFamily
IPR033695 Second polo-box domainDomainDomain
IPR033701 First polo-box domainDomainDomain
IPR036947 POLO box domain superfamilyFamilyHomologous superfamily
IPR042703 Serine/threonine-protein kinase PLK3, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
PLK3_HUMANPCH2_HUMANBioGRID, HPRD, IntAct16189514 details
PLK3_HUMANVRK1_HUMANHPRD, IntAct19103756 details
PLK3_HUMANPRIO_HUMANBioGRID, IntAct18482256 details
PLK3_HUMANPO2F1_HUMANBioGRID, IntAct25416956 details
PLK3_HUMANLSM5_HUMANBioGRID, IntAct32296183 details
PLK3_HUMANRAD52_HUMANBioGRID, IntAct32296183 details
PLK3_HUMANMFF_HUMANBioGRID, IntAct32296183 details
PLK3_HUMANRN141_HUMANBioGRID, IntAct32296183 details
PLK3_HUMANCIB1_HUMANBioGRID, HPRD10523297 11039900 details
PLK3_HUMANP53_HUMANBioGRID, HPRD10673501 11551930 11709713 12242661 12548019 details
PLK3_HUMANCHK2_HUMANBioGRID, HPRD10973490 11901158 12242661 12493754 12548019 details
PLK3_HUMANMPIP3_HUMANBioGRID, HPRD10557092 11333986 11551930 9278512 details
PLK3_HUMANAPRIO_HUMANBioGRID18482256 details
PLK3_HUMANAURKA_HUMANBioGRID15190214 details
PLK3_HUMANBUB1B_HUMANBioGRID15190214 details
PLK3_HUMANSYUA_HUMANBioGRID19889641 details
PLK3_HUMANSYUB_HUMANBioGRID19889641 details
PLK3_HUMANCENPU_HUMANBioGRID19597481 details
PLK3_HUMANB2CL1_HUMANBioGRID22617334 details
PLK3_HUMANHIF1A_HUMANBioGRID20889502 28515325 details
PLK3_HUMANPLK1_HUMANBioGRID12548019 details
PLK3_HUMANRIR2_HUMANBioGRID12548019 details
PLK3_HUMANPPM1A_HUMANBioGRID12548019 details
PLK3_HUMANTNS2_HUMANBioGRID12548019 details
PLK3_HUMANSLX4_HUMANBioGRID12548019 details
PLK3_HUMANPTPRC_HUMANBioGRID11551930 details
PLK3_HUMANSIAH2_HUMANBioGRID28515325 details
PLK3_HUMANMP2K1_HUMANHPRD15021912 details
PLK3_HUMANMK01_HUMANHPRD15021912 details