Entity Details

Primary name MEFV_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15553
EntryNameMEFV_HUMAN
FullNamePyrin
TaxID9606
Evidenceevidence at protein level
Length781
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesMEFV

GO terms

Show/Hide Table
GOName
GO:0001726 ruffle
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0006954 inflammatory response
GO:0008270 zinc ion binding
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0016567 protein ubiquitination
GO:0030027 lamellipodium
GO:0031410 cytoplasmic vesicle
GO:0032651 regulation of interleukin-1 beta production
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032695 negative regulation of interleukin-12 production
GO:0034341 response to interferon-gamma
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042802 identical protein binding
GO:0045087 innate immune response
GO:0050728 negative regulation of inflammatory response
GO:0061630 ubiquitin protein ligase activity
GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1900226 negative regulation of NLRP3 inflammasome complex assembly
GO:1904270 pyroptosome complex assembly
GO:2001056 positive regulation of cysteine-type endopeptidase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cell projection
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR003877 SPRY domainDomainDomain
IPR003879 Butyrophylin-like, SPRY domainDomainDomain
IPR004020 DAPIN domainDomainDomain
IPR006574 SPRY-associatedDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR028841 PyrinFamilyFamily
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table