Entity Details

Primary name TLR7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NYK1
EntryNameTLR7_HUMAN
FullNameToll-like receptor 7
TaxID9606
Evidenceevidence at protein level
Length1049
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesTLR7

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001932 regulation of protein phosphorylation
GO:0002224 toll-like receptor signaling pathway
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004888 transmembrane signaling receptor activity
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0032009 early phagosome
GO:0032722 positive regulation of chemokine production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0034154 toll-like receptor 7 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0035197 siRNA binding
GO:0036020 endolysosome membrane
GO:0038187 pattern recognition receptor activity
GO:0043235 receptor complex
GO:0045087 innate immune response
GO:0050729 positive regulation of inflammatory response
GO:0051607 defense response to virus
GO:0071260 cellular response to mechanical stimulus
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017241 Toll-like receptorFamilyFamily
IPR026906 BspA type Leucine rich repeat regionRepeatRepeat
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00724 ImiquimodDrugbanksmall molecule
DB01611 HydroxychloroquineDrugbanksmall molecule
DB04860 IsatoribineDrugbanksmall molecule
DB05127 ANA971Drugbanksmall molecule
DB05475 GolotimodDrugbanksmall molecule
DB06530 ResiquimodDrugbanksmall molecule