Entity Details

Primary name M3K20_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NYL2
EntryNameM3K20_HUMAN
FullNameMitogen-activated protein kinase kinase kinase 20
TaxID9606
Evidenceevidence at protein level
Length800
SequenceStatuscomplete
DateCreated2005-07-05
DateModified2021-06-02

Ontological Relatives

GenesMAP3K20

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000186 obsolete activation of MAPKK activity
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007010 cytoskeleton organization
GO:0007257 obsolete activation of JUN kinase activity
GO:0008219 cell death
GO:0030154 cell differentiation
GO:0042733 embryonic digit morphogenesis
GO:0043065 positive regulation of apoptotic process
GO:0051403 stress-activated MAPK cascade
GO:0060173 limb development
GO:0071480 cellular response to gamma radiation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904291 positive regulation of mitotic DNA damage checkpoint

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001660 Sterile alpha motif domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
M3K20_HUMANM3K20_HUMANBioGRID, HPRD, IntAct10924358 15485649 17192257 details
M3K20_HUMANZN567_HUMANBioGRID, HPRD, IntAct, MINT16189514 21516116 25416956 31515488 32296183 details
M3K20_HUMAN1433Z_HUMANBioGRID, IntAct21988832 28514442 details
M3K20_HUMANKS6A5_HUMANBioGRID, IntAct21988832 details
M3K20_HUMANCCD69_HUMANBioGRID, MINT21900206 details
M3K20_HUMANDPYL1_HUMANBioGRID, MINT21900206 details
M3K20_HUMANDDAH2_HUMANBioGRID, MINT21900206 details
M3K20_HUMANEZH2_HUMANBioGRID, MINT21900206 details
M3K20_HUMANIGHM_HUMANMINT21900206 details
M3K20_HUMANITSN1_HUMANBioGRID, MINT21900206 details
M3K20_HUMANMIDN_HUMANBioGRID, MINT21900206 details
M3K20_HUMANEM55_HUMANBioGRID, MINT21900206 details
M3K20_HUMANRBX1_HUMANBioGRID, MINT21900206 details
M3K20_HUMANRN19A_HUMANBioGRID, MINT21900206 details
M3K20_HUMANSNF5_HUMANBioGRID, MINT21900206 details
M3K20_HUMANU119A_HUMANBioGRID, MINT21900206 details
M3K20_HUMANVP33B_HUMANBioGRID, MINT21900206 details
M3K20_HUMANZN593_HUMANBioGRID, MINT21900206 details
M3K20_HUMANZN746_HUMANBioGRID, MINT21900206 details
M3K20_HUMANZN775_HUMANBioGRID, MINT21900206 details
M3K20_HUMANZFP2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
M3K20_HUMANZFP1_HUMANBioGRID, IntAct32296183 details
M3K20_HUMANZN660_HUMANBioGRID, IntAct32296183 details
M3K20_HUMANZNF35_HUMANBioGRID, IntAct32296183 details
M3K20_HUMANZNF71_HUMANBioGRID, IntAct28514442 32296183 details
M3K20_HUMANZN33A_HUMANBioGRID, HPRD12535642 details
M3K20_HUMANNED4L_HUMANBioGRID19953087 details
M3K20_HUMANSRPK2_HUMANBioGRID26167880 details
M3K20_HUMANPKN1_HUMANIntAct12761180 details
M3K20_HUMAN1433G_HUMANHPRD, IntAct15324660 17353931 28514442 details
M3K20_HUMAN1433S_HUMANBioGRID, MINT15778465 details
M3K20_HUMANMP2K7_HUMANBioGRID, HPRD11836244 15465036 details
M3K20_HUMANTGFR1_HUMANBioGRID, HPRD15465036 details
M3K20_HUMANMP2K6_HUMANHPRD11836244 details
M3K20_HUMANMP2K4_HUMANHPRD11836244 details