Entity Details

Primary name ACTN4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43707
EntryNameACTN4_HUMAN
FullNameAlpha-actinin-4
TaxID9606
Evidenceevidence at protein level
Length911
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesACTN4

GO terms

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GOName
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001666 response to hypoxia
GO:0001725 stress fiber
GO:0001882 nucleoside binding
GO:0002576 platelet degranulation
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0015031 protein transport
GO:0016604 nuclear body
GO:0030050 vesicle transport along actin filament
GO:0030335 positive regulation of cell migration
GO:0030374 nuclear receptor coactivator activity
GO:0031093 platelet alpha granule lumen
GO:0031143 pseudopodium
GO:0031490 chromatin DNA binding
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0042974 retinoic acid receptor binding
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0044325 transmembrane transporter binding
GO:0047485 protein N-terminus binding
GO:0048384 retinoic acid receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051015 actin filament binding
GO:0051272 positive regulation of cellular component movement
GO:0070062 extracellular exosome
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903506 regulation of nucleic acid-templated transcription
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014837 EF-hand, Ca insensitiveDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
603278 OMIMFocal segmental glomerulosclerosis 1 (FSGS1)A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. The disease is caused by variants affecting the gene represented in this entry.

Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
ACTN4_HUMANMYOZ2_HUMANBioGRID, HPRD, IntAct16189514 19447967 25416956 25910212 26871637 32296183 details
ACTN4_HUMANMYOZ1_HUMANBioGRID, HPRD, IntAct16189514 details
ACTN4_HUMANPDLI1_HUMANBioGRID, HPRD, IntAct10753915 16189514 26186194 28514442 29892012 details
ACTN4_HUMANCOIL_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN4_HUMANSACS_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN4_HUMANCTNB1_HUMANBioGRID, IntAct16204054 25241761 details
ACTN4_HUMANCDN2A_HUMANBioGRID, IntAct17955473 details
ACTN4_HUMANNOS3_HUMANBioGRID, IntAct21163940 details
ACTN4_HUMANSTAT1_HUMANBioGRID, IntAct20936779 details
ACTN4_HUMANATX7_HUMANBioGRID, IntAct21078624 details
ACTN4_HUMANPOTE1_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANIMA1_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANMK07_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANRS27_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANTHIO_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANTITIN_HUMANBioGRID, IntAct23414517 details
ACTN4_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
ACTN4_HUMANAP2C_HUMANIntAct24835590 details
ACTN4_HUMANAP2A_HUMANIntAct24835590 details
ACTN4_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 26320552 31980649 details
ACTN4_HUMANESR1_HUMANBioGRID, IntAct21078666 25604459 details
ACTN4_HUMANNHRF2_HUMANBioGRID, HPRD, IntAct11948184 27173435 unassigned1312 details
ACTN4_HUMANSCRIB_HUMANMINT24550280 details
ACTN4_HUMANCN119_HUMANBioGRID, IntAct32296183 details
ACTN4_HUMANMILK2_HUMANBioGRID, IntAct32296183 details
ACTN4_HUMANACTN3_HUMANBioGRID, HPRD, IntAct10656685 25416956 32296183 details
ACTN4_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
ACTN4_HUMANSRBS2_HUMANBioGRID, IntAct25910212 details
ACTN4_HUMANTYW4_HUMANBioGRID, IntAct25910212 details
ACTN4_HUMANMEOX2_HUMANBioGRID, IntAct25910212 details
ACTN4_HUMANRARA_HUMANBioGRID, DIP22351778 details
ACTN4_HUMANPE2R4_HUMANBioGRID, MINT28298427 details
ACTN4_HUMANCOHA1_HUMANBioGRID, HPRD11739652 details
ACTN4_HUMANTRIM3_HUMANBioGRID, HPRD10673389 15772161 30542119 details
ACTN4_HUMANMAGI1_HUMANBioGRID, HPRD12042308 details
ACTN4_HUMANGELS_HUMANBioGRID, HPRD11733011 details
ACTN4_HUMANKCC2A_HUMANBioGRID11160423 details
ACTN4_HUMANKCC2B_HUMANBioGRID, HPRD11160423 details
ACTN4_HUMANINO80_HUMANBioGRID20197409 details
ACTN4_HUMANHDAC7_HUMANBioGRID16980305 details
ACTN4_HUMANMEF2A_HUMANBioGRID16980305 details
ACTN4_HUMANUCHL5_HUMANBioGRID21800051 details
ACTN4_HUMANVDR_HUMANBioGRID21078666 details
ACTN4_HUMANHGS_HUMANBioGRID15772161 22863883 26819309 details
ACTN4_HUMANARF_HUMANBioGRID17955473 details
ACTN4_HUMANBMP7_HUMANBioGRID25416956 details
ACTN4_HUMANDDIAS_HUMANBioGRID28079882 details
ACTN4_HUMANTRI23_HUMANBioGRID26871637 details
ACTN4_HUMANLRRC7_HUMANHPRD11160423 details
ACTN4_HUMANAA2AR_HUMANHPRD12837758 details
ACTN4_HUMANPAI1_HUMANHPRD15493875 details
ACTN4_HUMANM3K3_HUMANIntAct14743216 details
ACTN4_HUMANRIPK3_HUMANIntAct14743216 details
ACTN4_HUMAN1433Z_HUMANMINT15161933 details
ACTN4_HUMANZO1_HUMANBioGRID, HPRD, IntAct16944923 details
ACTN4_HUMANIQGA1_HUMANBioGRID, IntAct22662192 26496610 details
ACTN4_HUMANPPARG_HUMANDIP22351778 details
ACTN4_HUMANACTN4_HUMANDIP22351778 details
ACTN4_HUMANUS6NL_HUMANBioGRID, HPRD15152255 details
ACTN4_HUMANUBF1_HUMANBioGRID20197409 details
ACTN4_HUMANHDAC5_HUMANBioGRID21081666 details
ACTN4_HUMANGLUT4_HUMANBioGRID, HPRD16396496 details
ACTN4_HUMANISG15_HUMANBioGRID16009940 33024031 details
ACTN4_HUMANITA4_HUMANBioGRID22623428 details
ACTN4_HUMANSVIL_HUMANBioGRID, HPRD12202484 details
ACTN4_HUMANGBB2_HUMANBioGRID23326349 details
ACTN4_HUMANNFYA_HUMANBioGRID15364540 details
ACTN4_HUMANACTS_HUMANBioGRID19920151 details
ACTN4_HUMANCDK9_HUMANBioGRID26209609 details
ACTN4_HUMANACTC_HUMANBioGRID, HPRD12042308 30890647 details
ACTN4_HUMANTF65_HUMANBioGRID30542119 details
ACTN4_HUMANANM5_HUMANBioGRID30542119 details
ACTN4_HUMANNMDZ1_HUMANBioGRID16510730 details
ACTN4_HUMANRGS9_HUMANBioGRID16510730 details
ACTN4_HUMANSOX2_HUMANBioGRID21280222 details
ACTN4_HUMANPTN11_HUMANHPRD11382784 details
ACTN4_HUMANVATB1_HUMANHPRD10915794 details
ACTN4_HUMANPTN6_HUMANHPRD15070900 15588985 details
ACTN4_HUMANNEBU_HUMANHPRD11882289 details
ACTN4_HUMANNOS2_HUMANHPRD12960352 details