Entity Details

Primary name PHF8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UPP1
EntryNamePHF8_HUMAN
FullNameHistone lysine demethylase PHF8
TaxID9606
Evidenceevidence at protein level
Length1060
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesPHF8

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0003682 chromatin binding
GO:0003712 transcription coregulator activity
GO:0005506 iron ion binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006482 protein demethylation
GO:0007076 mitotic chromosome condensation
GO:0007420 brain development
GO:0008270 zinc ion binding
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0031965 nuclear membrane
GO:0032452 histone demethylase activity
GO:0032454 histone demethylase activity (H3-K9 specific)
GO:0033169 histone H3-K9 demethylation
GO:0035064 methylated histone binding
GO:0035574 histone H4-K20 demethylation
GO:0035575 histone demethylase activity (H4-K20 specific)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0051864 histone demethylase activity (H3-K36 specific)
GO:0061188 negative regulation of ribosomal DNA heterochromatin assembly
GO:0070544 histone H3-K36 demethylation
GO:0071557 histone H3-K27 demethylation
GO:0071558 histone demethylase activity (H3-K27 specific)

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR003347 JmjC domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR041070 Jumonji, helical domainDomainDomain

Diseases

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Disease IDSourceNameDescription
300263 OMIMMental retardation, X-linked, syndromic, Siderius type (MRXSSD)A syndrome characterized by mild to borderline mental retardation with or without cleft lip/cleft palate. The disease is caused by variants affecting the gene represented in this entry.

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
PHF8_HUMANRARA_HUMANBioGRID, IntAct20548336 23518351 details
PHF8_HUMANH31_HUMANBioGRID, IntAct20208542 20346720 20421419 20531378 20548336 20622853 26496610 details
PHF8_HUMANZN711_HUMANBioGRID20346720 details
PHF8_HUMANH4_HUMANBioGRID20622853 30804502 details
PHF8_HUMANRPB1_HUMANBioGRID20421419 details
PHF8_HUMANH31T_HUMANBioGRID20850016 20953165 21029866 details
PHF8_HUMANA4_HUMANBioGRID21244100 21832049 details
PHF8_HUMANSUMO2_HUMANBioGRID19394292 details
PHF8_HUMANUBP7_HUMANBioGRID27183383 details
PHF8_HUMANTOPB1_HUMANBioGRID33010150 details
PHF8_HUMANCCNA2_HUMANBioGRID, IntAct26186194 28514442 33010150 details
PHF8_HUMANHCFC1_HUMANBioGRID, DIP20622854 details
PHF8_HUMANWDR5_HUMANBioGRID20208542 details
PHF8_HUMANASH2L_HUMANBioGRID20208542 details
PHF8_HUMANRPB3_HUMANBioGRID20421419 details
PHF8_HUMANTAF1_HUMANBioGRID20421419 details
PHF8_HUMANCDC27_HUMANBioGRID23979597 details
PHF8_HUMANCDC23_HUMANBioGRID23979597 details
PHF8_HUMANAPC1_HUMANBioGRID23979597 details
PHF8_HUMANAPC5_HUMANBioGRID23979597 details
PHF8_HUMANCDC26_HUMANBioGRID23979597 details
PHF8_HUMANAPC4_HUMANBioGRID23979597 details
PHF8_HUMANCDC16_HUMANBioGRID23979597 details
PHF8_HUMANAPC7_HUMANBioGRID23979597 details
PHF8_HUMANANC2_HUMANBioGRID23979597 details
PHF8_HUMANCDC20_HUMANBioGRID23979597 details
PHF8_HUMANFZR1_HUMANBioGRID23979597 details
PHF8_HUMANBLM_HUMANBioGRID27183383 details
PHF8_HUMANOGT1_HUMANBioGRID27183383 details
PHF8_HUMANHSP7C_HUMANBioGRID27183383 details
PHF8_HUMANLSM4_HUMANBioGRID29395067 details
PHF8_HUMANZN263_HUMANBioGRID32051553 details
PHF8_HUMANCDK2_HUMANBioGRID33010150 details
PHF8_HUMANSMC2_HUMANBioGRID33010150 details
PHF8_HUMANTULP3_HUMANBioGRID33187986 details