Entity Details

Primary name PTN22_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2R2
EntryNamePTN22_HUMAN
FullNameTyrosine-protein phosphatase non-receptor type 22
TaxID9606
Evidenceevidence at protein level
Length807
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesPTPN22

GO terms

Show/Hide Table
GOName
GO:0002230 positive regulation of defense response to virus by host
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0006914 autophagy
GO:0009898 cytoplasmic side of plasma membrane
GO:0010507 negative regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
GO:0019900 kinase binding
GO:0030217 T cell differentiation
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032715 negative regulation of interleukin-6 production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032817 regulation of natural killer cell proliferation
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway
GO:0034165 positive regulation of toll-like receptor 9 signaling pathway
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035644 phosphoanandamide dephosphorylation
GO:0043508 negative regulation of JUN kinase activity
GO:0045088 regulation of innate immune response
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071225 cellular response to muramyl dipeptide
GO:0071663 positive regulation of granzyme B production
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1903753 negative regulation of p38MAPK cascade
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR016276 Non-receptor tyrosine-protein phosphatase 22FamilyFamily
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily

Diseases

Show/Hide Table