Entity Details

Primary name HRH3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5N1
EntryNameHRH3_HUMAN
FullNameHistamine H3 receptor
TaxID9606
Evidenceevidence at protein level
Length445
SequenceStatuscomplete
DateCreated2001-11-16
DateModified2021-06-02

Ontological Relatives

GenesHRH3

GO terms

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GOName
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0014050 negative regulation of glutamate secretion
GO:0014061 regulation of norepinephrine secretion
GO:0014063 negative regulation of serotonin secretion
GO:0016907 G protein-coupled acetylcholine receptor activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0045202 synapse
GO:0050890 cognition
GO:0098793 presynapse

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR003980 Histamine H3 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00768 OlopatadineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB05080 OBE101Drugbanksmall molecule
DB05381 HistamineDrugbanksmall molecule
DB06698 BetahistineDrugbanksmall molecule
DB11642 PitolisantDrugbanksmall molecule