Entity Details

Primary name NFS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y697
EntryNameNFS1_HUMAN
FullNameCysteine desulfurase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length457
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesNFS1

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0016226 iron-sulfur cluster assembly
GO:0018283 iron incorporation into metallo-sulfur cluster
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
GO:0032324 molybdopterin cofactor biosynthetic process
GO:0042803 protein homodimerization activity
GO:0044571 [2Fe-2S] cluster assembly
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000192 Aminotransferase class V domainDomainDomain
IPR010240 Cysteine desulfurase IscSFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily
IPR016454 Cysteine desulfuraseFamilyFamily
IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00151 CysteineDrugbanksmall molecule
DB00160 AlanineDrugbanksmall molecule