Entity Details

Primary name LRP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75096
EntryNameLRP4_HUMAN
FullNameLow-density lipoprotein receptor-related protein 4
TaxID9606
Evidenceevidence at protein level
Length1905
SequenceStatuscomplete
DateCreated2004-04-13
DateModified2021-06-02

Ontological Relatives

GenesLRP4

GO terms

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GOName
GO:0001822 kidney development
GO:0001942 hair follicle development
GO:0005509 calcium ion binding
GO:0005886 plasma membrane
GO:0006897 endocytosis
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0016055 Wnt signaling pathway
GO:0030279 negative regulation of ossification
GO:0030425 dendrite
GO:0030971 receptor tyrosine kinase binding
GO:0031594 neuromuscular junction
GO:0034185 apolipoprotein binding
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0044853 plasma membrane raft
GO:0048813 dendrite morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050771 negative regulation of axonogenesis
GO:0050808 synapse organization
GO:0051124 synaptic assembly at neuromuscular junction
GO:0060173 limb development
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097060 synaptic membrane
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:0097110 scaffold protein binding
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1901631 positive regulation of presynaptic membrane organization
GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
LRP4_HUMANWHRN_HUMANBioGRID, HPRD, IntAct12421765 details
LRP4_HUMANSOST_HUMANBioGRID, IntAct, UniProt21471202 28514442 details
LRP4_HUMANPCLI1_HUMANBioGRID20205790 details
LRP4_HUMANOGT1_HUMANBioGRID32994395 details