Entity Details

Primary name CDKL5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO76039
EntryNameCDKL5_HUMAN
FullNameCyclin-dependent kinase-like 5
TaxID9606
Evidenceevidence at protein level
Length960
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCDKL5

GO terms

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GOName
GO:0001764 neuron migration
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005813 centrosome
GO:0006468 protein phosphorylation
GO:0016301 kinase activity
GO:0031267 small GTPase binding
GO:0032587 ruffle membrane
GO:0032839 dendrite cytoplasm
GO:0036064 ciliary basal body
GO:0043547 positive regulation of GTPase activity
GO:0044294 dendritic growth cone
GO:0045773 positive regulation of axon extension
GO:0046777 protein autophosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0050773 regulation of dendrite development
GO:0050775 positive regulation of dendrite morphogenesis
GO:0060999 positive regulation of dendritic spine development
GO:0097542 ciliary tip
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:0099175 regulation of postsynapse organization
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902017 regulation of cilium assembly

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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