Entity Details

Primary name SLIT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO94813
EntryNameSLIT2_HUMAN
FullNameSlit homolog 2 protein
TaxID9606
Evidenceevidence at protein level
Length1529
SequenceStatuscomplete
DateCreated2003-07-19
DateModified2021-06-02

Ontological Relatives

GenesSLIT2

GO terms

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GOName
GO:0001657 ureteric bud development
GO:0001933 negative regulation of protein phosphorylation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002689 negative regulation of leukocyte chemotaxis
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0005095 GTPase inhibitor activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0007411 axon guidance
GO:0008045 motor neuron axon guidance
GO:0008201 heparin binding
GO:0009986 cell surface
GO:0010593 negative regulation of lamellipodium assembly
GO:0010596 negative regulation of endothelial cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016020 membrane
GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021972 corticospinal neuron axon guidance through spinal cord
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030837 negative regulation of actin filament polymerization
GO:0031290 retinal ganglion cell axon guidance
GO:0032870 cellular response to hormone stimulus
GO:0035385 Roundabout signaling pathway
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0043237 laminin-1 binding
GO:0043394 proteoglycan binding
GO:0048495 Roundabout binding
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048846 axon extension involved in axon guidance
GO:0050772 positive regulation of axonogenesis
GO:0050919 negative chemotaxis
GO:0050929 induction of negative chemotaxis
GO:0051058 negative regulation of small GTPase mediated signal transduction
GO:0051414 response to cortisol
GO:0060412 ventricular septum morphogenesis
GO:0061364 apoptotic process involved in luteolysis
GO:0070062 extracellular exosome
GO:0070100 negative regulation of chemokine-mediated signaling pathway
GO:0071504 cellular response to heparin
GO:0071672 negative regulation of smooth muscle cell chemotaxis
GO:0071676 negative regulation of mononuclear cell migration
GO:0090024 negative regulation of neutrophil chemotaxis
GO:0090027 negative regulation of monocyte chemotaxis
GO:0090260 negative regulation of retinal ganglion cell axon guidance
GO:0090288 negative regulation of cellular response to growth factor stimulus

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000372 Leucine-rich repeat N-terminal domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR001791 Laminin G domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR003645 Follistatin-like, N-terminalDomainDomain
IPR006207 Cystine knot, C-terminalDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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