Entity Details

Primary name HAND1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO96004
EntryNameHAND1_HUMAN
FullNameHeart- and neural crest derivatives-expressed protein 1
TaxID9606
Evidenceevidence at protein level
Length215
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesHAND1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001221 transcription coregulator binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001707 mesoderm formation
GO:0001824 blastocyst development
GO:0001829 trophectodermal cell differentiation
GO:0001947 heart looping
GO:0003144 embryonic heart tube formation
GO:0003218 cardiac left ventricle formation
GO:0003219 cardiac right ventricle formation
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0032502 developmental process
GO:0035050 embryonic heart tube development
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060411 cardiac septum morphogenesis
GO:0060485 mesenchyme development
GO:0060536 cartilage morphogenesis
GO:0060707 trophoblast giant cell differentiation
GO:0090575 RNA polymerase II transcription regulator complex
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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