Entity Details

Primary name ASSY_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00966
EntryNameASSY_HUMAN
FullNameArgininosuccinate synthase
TaxID9606
Evidenceevidence at protein level
Length412
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesASS1

GO terms

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GOName
GO:0000050 urea cycle
GO:0000052 citrulline metabolic process
GO:0000053 argininosuccinate metabolic process
GO:0001822 kidney development
GO:0001889 liver development
GO:0003723 RNA binding
GO:0004055 argininosuccinate synthase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006526 arginine biosynthetic process
GO:0006531 aspartate metabolic process
GO:0006953 acute-phase response
GO:0007494 midgut development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007623 circadian rhythm
GO:0010043 response to zinc ion
GO:0010046 response to mycotoxin
GO:0015643 toxic substance binding
GO:0016597 amino acid binding
GO:0032355 response to estradiol
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043204 perikaryon
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0060416 response to growth hormone
GO:0060539 diaphragm development
GO:0070062 extracellular exosome
GO:0070852 cell body fiber
GO:0071222 cellular response to lipopolysaccharide
GO:0071230 cellular response to amino acid stimulus
GO:0071242 cellular response to ammonium ion
GO:0071320 cellular response to cAMP
GO:0071346 cellular response to interferon-gamma
GO:0071356 cellular response to tumor necrosis factor
GO:0071377 cellular response to glucagon stimulus
GO:0071400 cellular response to oleic acid
GO:0071418 cellular response to amine stimulus
GO:0071499 cellular response to laminar fluid shear stress
GO:0071549 cellular response to dexamethasone stimulus
GO:1903038 negative regulation of leukocyte cell-cell adhesion

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001518 Argininosuccinate synthaseFamilyFamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR018223 Argininosuccinate synthase, conserved siteSiteConserved site
IPR023434 Argininosuccinate synthase, type 1 subfamilyFamilyFamily
IPR024074 Argininosuccinate synthetase, catalytic/multimerisation domain bodyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00125 ArginineDrugbanksmall molecule
DB00128 Aspartic acidDrugbanksmall molecule
DB00155 CitrullineDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule