Entity Details

Primary name PDGFB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01127
EntryNamePDGFB_HUMAN
FullNamePlatelet-derived growth factor subunit B
TaxID9606
Evidenceevidence at protein level
Length241
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPDGFB

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000165 MAPK cascade
GO:0001892 embryonic placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002548 monocyte chemotaxis
GO:0002576 platelet degranulation
GO:0003104 positive regulation of glomerular filtration
GO:0005161 platelet-derived growth factor receptor binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0006468 protein phosphorylation
GO:0007507 heart development
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0009611 response to wounding
GO:0009986 cell surface
GO:0010512 negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 negative regulation of platelet activation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0016323 basolateral plasma membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031093 platelet alpha granule lumen
GO:0031954 positive regulation of protein autophosphorylation
GO:0032091 negative regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0035655 interleukin-18-mediated signaling pathway
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038001 paracrine signaling
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045840 positive regulation of mitotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046982 protein heterodimerization activity
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048146 positive regulation of fibroblast proliferation
GO:0048407 platelet-derived growth factor binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050921 positive regulation of chemotaxis
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0062023 collagen-containing extracellular matrix
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0070851 growth factor receptor binding
GO:0071363 cellular response to growth factor stimulus
GO:0071506 cellular response to mycophenolic acid
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0072255 metanephric glomerular mesangial cell development
GO:0072593 reactive oxygen species metabolic process
GO:0090280 positive regulation of calcium ion import
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
GO:1905176 positive regulation of vascular associated smooth muscle cell dedifferentiation
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000591 positive regulation of metanephric mesenchymal cell migration

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000072 PDGF/VEGF domainDomainDomain
IPR006782 Platelet-derived growth factor, N-terminalDomainDomain
IPR015583 Platelet-derived growth factor subunit BFamilyFamily
IPR023581 Platelet-derived growth factor, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06325 PegpleranibDrugbanksmall molecule

Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
PDGFB_HUMANPGFRB_HUMANBioGRID, DIP, HPRD, IntAct10806482 11297552 11903042 17981115 18593464 20534510 20577048 7679113 details
PDGFB_HUMANMDFI_HUMANBioGRID, IntAct19060904 details
PDGFB_HUMANPDGFB_HUMANBioGRID, DIP, HPRD, IntAct1396586 23139410 7679113 details
PDGFB_HUMANPDGFA_HUMANIntAct7679113 details
PDGFB_HUMANPGFRA_HUMANBioGRID, DIP, HPRD, IntAct10806482 11297552 15767546 2544881 7679113 9677323 details
PDGFB_HUMANBCCIP_HUMANBioGRID, IntAct32296183 details
PDGFB_HUMANLRP1_HUMANBioGRID, HPRD11854294 details
PDGFB_HUMANSPRC_HUMANBioGRID1311092 details
PDGFB_HUMANTSP1_HUMANBioGRID, HPRD9334164 details
PDGFB_HUMANPGBM_HUMANBioGRID, HPRD9692901 details
PDGFB_HUMANCO1A1_HUMANBioGRID, HPRD10446987 8900172 details
PDGFB_HUMANCO1A2_HUMANBioGRID8900172 details
PDGFB_HUMANCO2A1_HUMANBioGRID8900172 details
PDGFB_HUMANCO3A1_HUMANBioGRID8900172 details
PDGFB_HUMANCO4A1_HUMANBioGRID8900172 details
PDGFB_HUMANCO5A1_HUMANBioGRID8900172 details
PDGFB_HUMANCO6A1_HUMANBioGRID8900172 details
PDGFB_HUMANLYVE1_HUMANBioGRID7829517 details
PDGFB_HUMANFBX7_HUMANBioGRID27503909 details
PDGFB_HUMANP85A_HUMANBioGRID1372091 details
PDGFB_HUMANHAP28_HUMANBioGRID, HPRD8780057 details
PDGFB_HUMANADIPO_HUMANBioGRID12070119 details
PDGFB_HUMANNRP1_HUMANBioGRID16847823 20577048 details
PDGFB_HUMANRASH_HUMANHPRD10485711 details
PDGFB_HUMANNAR1_HUMANHPRD11498506 details
PDGFB_HUMANA2MG_HUMANHPRD10681572 details
PDGFB_HUMANHNRPC_HUMANHPRD10409733 details