Entity Details

Primary name LDLR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01130
EntryNameLDLR_HUMAN
FullNameLow-density lipoprotein receptor
TaxID9606
Evidenceevidence at protein level
Length860
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesLDLR

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001618 virus receptor activity
GO:0002020 protease binding
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005509 calcium ion binding
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 clathrin-coated pit
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0007616 long-term memory
GO:0008203 cholesterol metabolic process
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010899 regulation of phosphatidylcholine catabolic process
GO:0015914 phospholipid transport
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030229 very-low-density lipoprotein particle receptor activity
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032050 clathrin heavy chain binding
GO:0034362 low-density lipoprotein particle
GO:0034381 plasma lipoprotein particle clearance
GO:0034382 chylomicron remnant clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0036020 endolysosome membrane
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0051246 regulation of protein metabolic process
GO:0051248 negative regulation of protein metabolic process
GO:0061024 membrane organization
GO:0061771 response to caloric restriction
GO:0061889 negative regulation of astrocyte activation
GO:0070508 cholesterol import
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
GO:0097242 amyloid-beta clearance
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1903979 negative regulation of microglial cell activation
GO:1905167 positive regulation of lysosomal protein catabolic process
GO:1905907 negative regulation of amyloid fibril formation
GO:1990666 PCSK9-LDLR complex

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome
Golgi apparatus
Late endosome
Lysosome
Membrane

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
143890 OMIMHypercholesterolemia, familial, 1 (FHCL1)A form of hypercholesterolemia, a disorder of lipoprotein metabolism characterized by elevated serum low-density lipoprotein (LDL) cholesterol levels, which result in excess deposition of cholesterol in tissues and leads to xanthelasma, xanthomas, accelerated atherosclerosis and increased risk of premature coronary heart disease. FHCL1 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00707 Porfimer sodiumDrugbanksmall molecule
DB09270 UbidecarenoneDrugbanksmall molecule
DB11251 TocopherolSwissprotsmall molecule
DB14003 alpha-Tocopherol acetateSwissprotsmall molecule

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
LDLR_HUMANPDIA3_HUMANBioGRID, MINT17170699 details
LDLR_HUMANCBP_HUMANBioGRID, MINT18660751 details
LDLR_HUMANMAP4_HUMANBioGRID, IntAct21988832 details
LDLR_HUMANPCSK9_HUMANBioGRID, DIP, HPRD, MINT17435765 18250299 18753623 22081141 23085658 25613181 details
LDLR_HUMANARH_HUMANbhf-ucl, BioGRID, HPRD12221107 12746448 details
LDLR_HUMANAPOB_HUMANHPRD, MINT12031600 24447298 details
LDLR_HUMANAPOE_HUMANHPRD, MINT, UniProt12036962 20030366 24447298 details
LDLR_HUMANLDLR_HUMANHPRD, MINT10884290 26526611 details
LDLR_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
LDLR_HUMANIF3M_HUMANBioGRID, IntAct32296183 details
LDLR_HUMANAMRP_HUMANBioGRID, HPRD, IntAct, UniProt20030366 28514442 7822276 details
LDLR_HUMANAPOH_HUMANDIP20223219 details
LDLR_HUMANDAB1_HUMANBioGRID, HPRD10380922 10827173 9837937 details
LDLR_HUMANPLF4_HUMANBioGRID, HPRD11986215 details
LDLR_HUMANCD36_HUMANBioGRID9555943 details
LDLR_HUMANDAB2_HUMANBioGRID11247302 details
LDLR_HUMANSNX17_HUMANBioGRID, HPRD12169628 details
LDLR_HUMANMYLIP_HUMANBioGRID21685362 21734303 22109552 23382078 26666640 32727844 details
LDLR_HUMANVGFR1_HUMANMINT17962812 details
LDLR_HUMANAP1M2_HUMANBioGRID, HPRD11157985 details
LDLR_HUMANBIP_HUMANBioGRID, HPRD10906332 16257961 details
LDLR_HUMANENPL_HUMANBioGRID16257961 details
LDLR_HUMANPDIA4_HUMANBioGRID16257961 details
LDLR_HUMANCALX_HUMANBioGRID16257961 details
LDLR_HUMANUBP2_HUMANBioGRID26666640 details
LDLR_HUMANFGF11_HUMANBioGRID28027390 details