Entity Details

Primary name IL1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01584
EntryNameIL1B_HUMAN
FullNameInterleukin-1 beta
TaxID9606
Evidenceevidence at protein level
Length269
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesIL1B

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001660 fever generation
GO:0001934 positive regulation of protein phosphorylation
GO:0002711 positive regulation of T cell mediated immunity
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007566 embryo implantation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010573 vascular endothelial growth factor production
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010829 negative regulation of glucose transmembrane transport
GO:0014805 smooth muscle adaptation
GO:0019221 cytokine-mediated signaling pathway
GO:0019904 protein domain specific binding
GO:0030213 hyaluronan biosynthetic process
GO:0030335 positive regulation of cell migration
GO:0030730 sequestering of triglyceride
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031622 positive regulation of fever generation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032308 positive regulation of prostaglandin secretion
GO:0032496 response to lipopolysaccharide
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0033129 positive regulation of histone phosphorylation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0035066 positive regulation of histone acetylation
GO:0035505 positive regulation of myosin light chain kinase activity
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035690 cellular response to drug
GO:0042102 positive regulation of T cell proliferation
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407 negative regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045833 negative regulation of lipid metabolic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045917 positive regulation of complement activation
GO:0046330 positive regulation of JNK cascade
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046827 positive regulation of protein export from nucleus
GO:0050729 positive regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050767 regulation of neurogenesis
GO:0050768 negative regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0050805 negative regulation of synaptic transmission
GO:0050995 negative regulation of lipid catabolic process
GO:0050996 positive regulation of lipid catabolic process
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051781 positive regulation of cell division
GO:0060252 positive regulation of glial cell proliferation
GO:0060355 positive regulation of cell adhesion molecule production
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0070164 negative regulation of adiponectin secretion
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070487 monocyte aggregation
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071310 cellular response to organic substance
GO:0071407 cellular response to organic cyclic compound
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0150078 positive regulation of neuroinflammatory response
GO:1900745 positive regulation of p38MAPK cascade
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902680 positive regulation of RNA biosynthetic process
GO:1903140 regulation of establishment of endothelial barrier
GO:1903597 negative regulation of gap junction assembly
GO:2000556 positive regulation of T-helper 1 cell cytokine production
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cytoplasm
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR000975 Interleukin-1 familyFamilyFamily
IPR003296 Interleukin-1 betaFamilyFamily
IPR003502 Interleukin-1 propeptideDomainDomain
IPR008996 Cytokine IL1/FGFFamilyHomologous superfamily
IPR020877 Interleukin-1 conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00843 DonepezilDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB05133 VP025Drugbanksmall molecule
DB05260 Gallium nitrateDrugbanksmall molecule
DB05412 TalmapimodDrugbanksmall molecule
DB05442 Etiprednol dicloacetateDrugbanksmall molecule
DB05470 VX-702Drugbanksmall molecule
DB05507 VX-765Drugbanksmall molecule
DB05767 AndrographolideDrugbanksmall molecule
DB06168 CanakinumabDrugbankbiotech
DB06372 RilonaceptDrugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB11967 BinimetinibDrugbanksmall molecule
DB12119 GevokizumabDrugbankbiotech
DB12140 DilmapimodDrugbanksmall molecule