Entity Details

Primary name IGKC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01834
EntryNameIGKC_HUMAN
FullNameImmunoglobulin kappa constant
TaxID9606
Evidenceevidence at protein level
Length107
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0001895 retina homeostasis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003823 antigen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0006910 phagocytosis, recognition
GO:0006911 phagocytosis, engulfment
GO:0006955 immune response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0008228 opsonization
GO:0009897 external side of plasma membrane
GO:0018149 peptide cross-linking
GO:0030449 regulation of complement activation
GO:0034987 immunoglobulin receptor binding
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042571 immunoglobulin complex, circulating
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0050776 regulation of immune response
GO:0050853 B cell receptor signaling pathway
GO:0050871 positive regulation of B cell activation
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01851 Tetrabutylammonium IonDrugbanksmall molecule
DB04688 MethylecgonineDrugbanksmall molecule
DB07375 EtiocholanedioneDrugbanksmall molecule
DB07416 (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATEDrugbanksmall molecule
DB07441 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACIDDrugbanksmall molecule
DB07716 (4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOLDrugbanksmall molecule
DB07784 [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACIDDrugbanksmall molecule
DB07882 4-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACIDDrugbanksmall molecule
DB07893 PHENYL[1-(N-SUCCINYLAMINO)PENTYL]PHOSPHONATEDrugbanksmall molecule
DB07909 (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOLDrugbanksmall molecule
DB08289 N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDEDrugbanksmall molecule
DB08413 METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTERDrugbanksmall molecule
DB08562 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACIDDrugbanksmall molecule
DB08647 TRAZEOLIDEDrugbanksmall molecule