Entity Details

Primary name FA11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP03951
EntryNameFA11_HUMAN
FullNameCoagulation factor XI
TaxID9606
Evidenceevidence at protein level
Length625
SequenceStatuscomplete
DateCreated1986-10-23
DateModified2021-06-02

Ontological Relatives

GenesF11

GO terms

Show/Hide Table
GOName
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0008201 heparin binding
GO:0016020 membrane
GO:0031639 plasminogen activation
GO:0042802 identical protein binding
GO:0051919 positive regulation of fibrinolysis
GO:0070009 serine-type aminopeptidase activity
GO:0070062 extracellular exosome

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000177 Apple domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR003609 PAN/Apple domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00100 Coagulation Factor IX (Recombinant)Drugbankbiotech
DB06404 Human C1-esterase inhibitorDrugbankbiotech
DB07022 3-Hydroxypropyl 3-[(7-carbamimidoyl-1-naphthyl)carbamoyl]benzenesulfonateDrugbanksmall molecule
DB07023 (1R)-2-[(Diaminomethylene)amino]-1-{4-[(4R)-4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl]phenyl}ethyl nicotinateDrugbanksmall molecule
DB07071 (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenethyl)guanidineDrugbanksmall molecule
DB07074 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTERDrugbanksmall molecule
DB07077 (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenyl)guanidineDrugbanksmall molecule
DB07212 N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDEDrugbanksmall molecule
DB07299 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDEDrugbanksmall molecule
DB07887 (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)benzyl)guanidineDrugbanksmall molecule
DB09228 Conestat alfaDrugbankbiotech
DB11300 ThrombinDrugbankbiotech
DB11571 Human thrombinDrugbankbiotech
DB13152 Coagulation Factor IX HumanDrugbankbiotech
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule