Entity Details

Primary name IL6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05231
EntryNameIL6_HUMAN
FullNameInterleukin-6
TaxID9606
Evidenceevidence at protein level
Length212
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesIL6

GO terms

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GOName
GO:0001781 neutrophil apoptotic process
GO:0002314 germinal center B cell differentiation
GO:0002384 hepatic immune response
GO:0002446 neutrophil mediated immunity
GO:0002548 monocyte chemotaxis
GO:0002639 positive regulation of immunoglobulin production
GO:0002675 positive regulation of acute inflammatory response
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005896 interleukin-6 receptor complex
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0006959 humoral immune response
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010573 vascular endothelial growth factor production
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010888 negative regulation of lipid storage
GO:0014823 response to activity
GO:0019221 cytokine-mediated signaling pathway
GO:0030168 platelet activation
GO:0031018 endocrine pancreas development
GO:0031175 neuron projection development
GO:0032494 response to peptidoglycan
GO:0032682 negative regulation of chemokine production
GO:0032722 positive regulation of chemokine production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032745 positive regulation of interleukin-21 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035633 maintenance of blood-brain barrier
GO:0042102 positive regulation of T cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045727 positive regulation of translation
GO:0045765 regulation of angiogenesis
GO:0045779 negative regulation of bone resorption
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 negative regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051607 defense response to virus
GO:0060252 positive regulation of glial cell proliferation
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0061470 T follicular helper cell differentiation
GO:0061888 regulation of astrocyte activation
GO:0070050 neuron cellular homeostasis
GO:0070091 glucagon secretion
GO:0070092 regulation of glucagon secretion
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0072540 T-helper 17 cell lineage commitment
GO:0072574 hepatocyte proliferation
GO:0090091 positive regulation of extracellular matrix disassembly
GO:0097421 liver regeneration
GO:0098586 cellular response to virus
GO:0150077 regulation of neuroinflammatory response
GO:0150078 positive regulation of neuroinflammatory response
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1903978 regulation of microglial cell activation
GO:1904894 positive regulation of receptor signaling pathway via STAT
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:2000553 positive regulation of T-helper 2 cell cytokine production
GO:2000635 negative regulation of primary miRNA processing
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway
GO:2000676 positive regulation of type B pancreatic cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR003574 Interleukin-6FamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily
IPR030473 Interleukin-6/GCSF/MGF, conserved siteSiteConserved site
IPR030474 Interleukin-6/GCSF/MGFFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01404 GinsengDrugbanksmall molecule
DB05017 YSIL6Drugbanksmall molecule
DB05470 VX-702Drugbanksmall molecule
DB05513 AtiprimodDrugbanksmall molecule
DB05744 CRx-139Drugbanksmall molecule
DB05767 AndrographolideDrugbanksmall molecule
DB06083 TapinarofDrugbanksmall molecule
DB09036 SiltuximabDrugbankbiotech
DB09221 PolaprezincDrugbanksmall molecule
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB11967 BinimetinibDrugbanksmall molecule
DB12140 DilmapimodDrugbanksmall molecule