Entity Details

Primary name HEPS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05981
EntryNameHEPS_HUMAN
FullNameSerine protease hepsin
TaxID9606
Evidenceevidence at protein level
Length417
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesHPN

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010756 positive regulation of plasminogen activation
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030307 positive regulation of cell growth
GO:0034769 basement membrane disassembly
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043923 positive regulation by host of viral transcription
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0070008 serine-type exopeptidase activity
GO:0070062 extracellular exosome
GO:0071805 potassium ion transmembrane transport
GO:0090103 cochlea morphogenesis
GO:0097066 response to thyroid hormone
GO:0097195 pilomotor reflex
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000611 positive regulation of thyroid hormone generation

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR015352 Hepsin, SRCR domainDomainDomain
IPR017448 SRCR-like domainDomainDomain
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR036772 SRCR-like domain superfamilyFamilyHomologous superfamily
IPR038957 HepsinFamilyFamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00522 BentiromideDrugbanksmall molecule
DB03297 Benzylsulfonic acidDrugbanksmall molecule
DB03643 CRA_1144Drugbanksmall molecule
DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineDrugbanksmall molecule